Helium-3 MR q-space imaging with radial acquisition and iterative highly constrained back-projection

Rafael L. O'Halloran, James H. Holmes, Yu Chien Wu, Andrew Alexander, Sean B. Fain

Research output: Contribution to journalArticle

16 Scopus citations


An undersampled diffusion-weighted stack-of-stars acquisition is combined with iterative highly constrained back-projection to perform hyperpolarized helium-3 MR q-space imaging with combined regional correction of radiofrequency- and T1-related signal loss in a single breath-held scan. The technique is tested in computer simulations and phantom experiments and demonstrated in a healthy human volunteer with whole-lung coverage in a 13-sec breath-hold. Measures of lung microstructure at three different lung volumes are evaluated using inhaled gas volumes of 500 mL, 1000 mL, and 1500 mL to demonstrate feasibility. Phantom results demonstrate that the proposed technique is in agreement with theoretical values, as well as with a fully sampled two-dimensional Cartesian acquisition. Results from the volunteer study demonstrate that the root mean squared diffusion distance increased significantly from the 500-mL volume to the 1000-mL volume. This technique represents the first demonstration of a spatially resolved hyperpolarized helium-3 q-space imaging technique and shows promise for microstructural evaluation of lung disease in three dimensions.

Original languageEnglish (US)
Pages (from-to)41-50
Number of pages10
JournalMagnetic Resonance in Medicine
Issue number1
StatePublished - Jan 1 2010
Externally publishedYes


  • Diffusion
  • HYPR
  • Helium-3
  • Hyperpolarized gase
  • Iterative reconstruction
  • MRI
  • Projection imaging
  • q-space

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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