Hematologic and hemorheological determinants of resting and exercise-induced hemoglobin oxygen desaturation in children with sickle cell disease

Xavier Waltz, Marc Romana, Marie Laure Lalanne-Mistrih, Roberto Machado, Yann Lamarre, Vanessa Tarer, Marie Dominique Hardy-Dessources, Benoît Tressières, Lydia Divialle-Doumdo, Marie Petras, Frederic Maillard, Maryse Etienne-Julan, Philippe Connes

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The aim of the study was to determine the factors associated with resting and exercise-induced hemoglobin oxygen desaturation. The well-established six-minute walk test was conducted in 107 sickle cell children (50 with sickle hemoglobin C disease and 57 with sickle cell anemia) at steady state. Hemoglobin oxygen saturation was measured before and immediately after the six-minute walk test. Blood samples were obtained on the same day to measure hematologic and hemorheological parameters. Exercise-induced hemoglobin oxygen desaturation was defined as a drop in hemoglobin oxygen saturation of 3% or more at the end of the six-minute walk test compared to resting levels. No children with sickle hemoglobin C disease, but approximately 50% of children with sickle cell anemia showed mild or moderate oxygen desaturation at rest, which was independently associated with the percentage of reticulocytes. Exercise-induced hemoglobin oxygen desaturation was observed in 18% of children with sickle hemoglobin C disease and 34% of children with sickle cell anemia, and was independently associated with the six-minute walk test, acute chest syndrome rate and the strength of red blood cell aggregates in children with sickle cell anemia. No association was found in children with sickle hemoglobin C disease between exerciseinduced hemoglobin oxygen desaturation and the measured parameters. Hemoglobin oxygen desaturation at rest was common in children with sickle cell anemia but not in children with sickle hemoglobin C disease, and was mainly associated with greater hemolysis. Physiological strain during exercise and red blood cell aggregation properties may predict the occurrence of exercise-induced hemoglobin oxygen desaturation in children with sickle cell anemia.

Original languageEnglish (US)
Pages (from-to)1039-1044
Number of pages6
JournalHaematologica
Volume98
Issue number7
DOIs
StatePublished - Jul 1 2013
Externally publishedYes

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Sickle Cell Anemia
Hemoglobin C Disease
Hemoglobins
Exercise
Oxygen
Sickle Hemoglobin
Erythrocytes
Acute Chest Syndrome
Cell Aggregation
Reticulocytes
Hemolysis
Walk Test

ASJC Scopus subject areas

  • Hematology

Cite this

Hematologic and hemorheological determinants of resting and exercise-induced hemoglobin oxygen desaturation in children with sickle cell disease. / Waltz, Xavier; Romana, Marc; Lalanne-Mistrih, Marie Laure; Machado, Roberto; Lamarre, Yann; Tarer, Vanessa; Hardy-Dessources, Marie Dominique; Tressières, Benoît; Divialle-Doumdo, Lydia; Petras, Marie; Maillard, Frederic; Etienne-Julan, Maryse; Connes, Philippe.

In: Haematologica, Vol. 98, No. 7, 01.07.2013, p. 1039-1044.

Research output: Contribution to journalArticle

Waltz, X, Romana, M, Lalanne-Mistrih, ML, Machado, R, Lamarre, Y, Tarer, V, Hardy-Dessources, MD, Tressières, B, Divialle-Doumdo, L, Petras, M, Maillard, F, Etienne-Julan, M & Connes, P 2013, 'Hematologic and hemorheological determinants of resting and exercise-induced hemoglobin oxygen desaturation in children with sickle cell disease', Haematologica, vol. 98, no. 7, pp. 1039-1044. https://doi.org/10.3324/haematol.2013.083576
Waltz, Xavier ; Romana, Marc ; Lalanne-Mistrih, Marie Laure ; Machado, Roberto ; Lamarre, Yann ; Tarer, Vanessa ; Hardy-Dessources, Marie Dominique ; Tressières, Benoît ; Divialle-Doumdo, Lydia ; Petras, Marie ; Maillard, Frederic ; Etienne-Julan, Maryse ; Connes, Philippe. / Hematologic and hemorheological determinants of resting and exercise-induced hemoglobin oxygen desaturation in children with sickle cell disease. In: Haematologica. 2013 ; Vol. 98, No. 7. pp. 1039-1044.
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