Hematologic malignancies of the liver: Spectrum of disease

Anderanik Tomasian, Kumar Sandrasegaran, Khaled M. Elsayes, Alampady Shanbhogue, Akram Shaaban, Christine O. Menias

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

The incidence of hematologic malignancies and their extranodal manifestations is continuously increasing. Previously unsuspected hepatic involvement in hematologic malignancies such as Hodgkin disease and non-Hodgkin lymphoma, posttransplant lymphoproliferative disorder, myeloid sarcoma (chloroma), multiple myeloma, Castleman disease, and lymphohistiocytosis may be seen by radiologists. Although the imaging features of more common hepatic diseases such as hepatocellular carcinoma, metastases, and infection may overlap with those of hepatic hematologic malignancies, combining the imaging features with clinical manifestations and laboratory findings can facilitate correct diagnosis. Clinical features that suggest a hematologic neoplasm as the cause of liver lesions include a young patient (<40 years of age), no known history of cancer, abnormal bone marrow biopsy results, fever of unknown origin, and night sweats. Imaging features that suggest hematologic malignancy include hepatosplenomegaly or splenic lesions, vascular encasement by a tumor without occlusion or thrombosis, an infiltrating mass at the hepatic hilum with no biliary obstruction, and widespread adenopathy above and below the diaphragm. Familiarity with the imaging features of hepatic hematologic malignancies permits correct provisional diagnosis and may influence therapeutic management. For example, when biopsy is performed, core biopsy may be needed in addition to fine-needle aspiration so that the tissue architecture of the neoplasm can be discerned. The predominant treatment of hematologic malignancies is chemotherapy or radiation therapy rather than surgery. Online supplemental material is available for this article.

Original languageEnglish (US)
Pages (from-to)71-86
Number of pages16
JournalRadiographics
Volume35
Issue number1
DOIs
StatePublished - Jan 1 2015

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Hematologic Neoplasms
Liver Diseases
Liver
Myeloid Sarcoma
Biopsy
Giant Lymph Node Hyperplasia
Fever of Unknown Origin
Bone Neoplasms
Lymphoproliferative Disorders
Sweat
Fine Needle Biopsy
Diaphragm
Multiple Myeloma
Hodgkin Disease
Non-Hodgkin's Lymphoma
Blood Vessels
Hepatocellular Carcinoma
Neoplasms
Thrombosis
Radiotherapy

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Tomasian, A., Sandrasegaran, K., Elsayes, K. M., Shanbhogue, A., Shaaban, A., & Menias, C. O. (2015). Hematologic malignancies of the liver: Spectrum of disease. Radiographics, 35(1), 71-86. https://doi.org/10.1148/rg.351130008

Hematologic malignancies of the liver : Spectrum of disease. / Tomasian, Anderanik; Sandrasegaran, Kumar; Elsayes, Khaled M.; Shanbhogue, Alampady; Shaaban, Akram; Menias, Christine O.

In: Radiographics, Vol. 35, No. 1, 01.01.2015, p. 71-86.

Research output: Contribution to journalArticle

Tomasian, A, Sandrasegaran, K, Elsayes, KM, Shanbhogue, A, Shaaban, A & Menias, CO 2015, 'Hematologic malignancies of the liver: Spectrum of disease', Radiographics, vol. 35, no. 1, pp. 71-86. https://doi.org/10.1148/rg.351130008
Tomasian A, Sandrasegaran K, Elsayes KM, Shanbhogue A, Shaaban A, Menias CO. Hematologic malignancies of the liver: Spectrum of disease. Radiographics. 2015 Jan 1;35(1):71-86. https://doi.org/10.1148/rg.351130008
Tomasian, Anderanik ; Sandrasegaran, Kumar ; Elsayes, Khaled M. ; Shanbhogue, Alampady ; Shaaban, Akram ; Menias, Christine O. / Hematologic malignancies of the liver : Spectrum of disease. In: Radiographics. 2015 ; Vol. 35, No. 1. pp. 71-86.
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