J. Hoggatt, Louis Pelus

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


Higher organisms have the capacity to produce blood cells throughout their life span to meet the normal physiological requirements of blood cell turnover as well as respond to needs for increased demand in response to injury or infection. An average sized human adult produces approximately one trillion blood cells every day. This lifelong process of continuous formation and turnover of blood cells is termed hematopoiesis. The long-term repopulating hematopoietic stem cell is the key cell producing both new stem cells, a process termed self-renewal, and all mature blood cells, a process termed differentiation. Self-renewal and proliferation of blood stem cells are regulated in both stochastic and instructive fashion orchestrated by growth factors, accessory cytokines, and cellular interactions within the hematopoietic niche. This article will provide a brief overview of the key findings that have contributed to the understanding of the capacity for lifelong blood cell production, including identification and characterization of stem cells and the lineage-restricted progenitor cells they produce, intrinsic and extrinsic regulation of stem cell function, methods used to evaluate stem cell function, and current and future therapeutic uses of hematopoietic stem cells.

Original languageEnglish (US)
Title of host publicationBrenner's Encyclopedia of Genetics
Subtitle of host publicationSecond Edition
PublisherElsevier Inc.
Number of pages4
ISBN (Electronic)9780080961569
ISBN (Print)9780123749840
StatePublished - Feb 27 2013
Externally publishedYes


  • Blood cell production
  • Hematopoiesis
  • Hematopoietic niche
  • Hematopoietic progenitor cell
  • Hematopoietic stem cell transplant
  • Lineage differentiation
  • Lineage restriction
  • Self-renewal
  • Stem cells

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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  • Cite this

    Hoggatt, J., & Pelus, L. (2013). Hematopoiesis. In Brenner's Encyclopedia of Genetics: Second Edition (pp. 418-421). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-374984-0.00686-0