Hematopoietic Reconstitution in a Patient with Fanconi's Anemia by Means of Umbilical-Cord Blood from an HLA-Identical Sibling

Eliane Gluckman, Hal E. Broxmeyer, Arleen D. Auerbach, Henry S. Friedman, Gordon W. Douglas, Agnès Devergie, Hélène Esperou, Dominique Thierry, Gérard Socie, Pierre Lehn, Scott Cooper, Denis English, Joanne Kurtzberg, Judith Bard, Edward A. Boyse

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Abstract

THE clinical manifestations of Fanconi's anemia, an autosomal recessive disorder, include progressive pancytopenia, a predisposition to neoplasia, and nonhematopoietic developmental anomalies.1 2 3 Hypersensitivity to the clastogenic effect of DNA–cross-linking agents such as diepoxybutane acts as a diagnostic indicator of the genotype of Fanconi's anemia, both prenatally and postnatally.3 4 5 6 Prenatal HLA typing has made it possible to ascertain whether a fetus is HLA-identical to an affected sibling.7 We report here on hematopoietic reconstitution in a boy with severe Fanconi's anemia who received cryopreserved umbilical-cord blood from a sister shown by prenatal testing to be unaffected by the disorder, to have a normal.

Original languageEnglish (US)
Pages (from-to)1174-1178
Number of pages5
JournalNew England Journal of Medicine
Volume321
Issue number17
DOIs
StatePublished - Oct 26 1989

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ASJC Scopus subject areas

  • Medicine(all)

Cite this

Gluckman, E., Broxmeyer, H. E., Auerbach, A. D., Friedman, H. S., Douglas, G. W., Devergie, A., Esperou, H., Thierry, D., Socie, G., Lehn, P., Cooper, S., English, D., Kurtzberg, J., Bard, J., & Boyse, E. A. (1989). Hematopoietic Reconstitution in a Patient with Fanconi's Anemia by Means of Umbilical-Cord Blood from an HLA-Identical Sibling. New England Journal of Medicine, 321(17), 1174-1178. https://doi.org/10.1056/NEJM198910263211707