Hematopoietic stem cell mobilization with agents other than G-CSF

Jonathan Hoggatt, Louis M. Pelus

Research output: Chapter in Book/Report/Conference proceedingChapter

14 Scopus citations

Abstract

Hematopoietic stem and progenitor mobilization has revolutionized the field of hematopoietic transplantation. Currently, hematopoietic grafts acquired from the peripheral blood of patients or donors treated with granulocyte-colony stimulating factor (G-CSF) are the preferred source for transplantation. G-CSF mobilization regimens, however, are associated with known morbidities and a significant number of normal donors and patient populations fail to mobilize sufficient numbers of hematopoietic stem and progenitor cells for transplantation, necessitating the need for non-G-CSF mobilization strategies. Mechanistic studies evaluating hematopoietic bone marrow niche interactions have uncovered novel agents with the capacity for hematopoietic mobilization. This chapter provides a comprehensive overview of mobilizing agents, other than G-CSF, and experimental procedures and technical aspects important to evaluate and define their hematopoietic mobilizing activities alone and in combination.

Original languageEnglish (US)
Title of host publicationStem Cell Mobilization
Subtitle of host publicationMethods and Protocols
PublisherHumana Press Inc.
Pages49-67
Number of pages19
ISBN (Print)9781617799426
DOIs
StatePublished - Jan 1 2012

Publication series

NameMethods in Molecular Biology
Volume904
ISSN (Print)1064-3745

Keywords

  • AMD3100
  • BIO5192
  • CXCR4
  • Fucoidan
  • G-CSF
  • GRO beta
  • Hematopoietic stem cells
  • Mobilization
  • SDF-1
  • VLA-4 inhibitor

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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  • Cite this

    Hoggatt, J., & Pelus, L. M. (2012). Hematopoietic stem cell mobilization with agents other than G-CSF. In Stem Cell Mobilization: Methods and Protocols (pp. 49-67). (Methods in Molecular Biology; Vol. 904). Humana Press Inc.. https://doi.org/10.1007/978-1-61779-943-3_4