Hematopoietic transcriptional regulation by the myeloid zinc finger gene, MZF-1

R. Hromas, B. Davis, F. J. Rauscher, M. Klemsz, D. Tenen, S. Hoffman, Dawei Xu, J. F. Morris

Research output: Contribution to journalArticle

77 Scopus citations

Abstract

Transcriptional regulators control much of hematopoiesis. One such transcriptional regulator is the myeloid zinc finger gene MZF-1. MZF-1 has been localized to the telomere of chromosome 19q, where a large number of related zinc finger genes reside. It has been found to be essential in granulopoiesis. It is a bi-functional transcriptional regulator, repressing transcription in non-hematopoietic cells, and activating transcription in cells of hematopoietic origins. Its consensus DNA binding site has been isolated, and sites in several promoters of myeloid-specific genes, such as CD34, lactoferrin, and myeloperoxidase, have been defined. In co-transfection experiments MZF-1 has been found to regulate transcription from the CD34 promoter.

Original languageEnglish (US)
Pages (from-to)158-164
Number of pages7
JournalCurrent Topics in Microbiology and Immunology
Volume211
StatePublished - Dec 1 1996

ASJC Scopus subject areas

  • Immunology and Allergy
  • Microbiology
  • Immunology
  • Microbiology (medical)

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    Hromas, R., Davis, B., Rauscher, F. J., Klemsz, M., Tenen, D., Hoffman, S., Xu, D., & Morris, J. F. (1996). Hematopoietic transcriptional regulation by the myeloid zinc finger gene, MZF-1. Current Topics in Microbiology and Immunology, 211, 158-164.