Hematopoietic transcriptional regulation by the myeloid zinc finger gene, MZF-1

R. Hromas, B. Davis, F. J. Rauscher, Michael Klemsz, D. Tenen, S. Hoffman, Dawei Xu, J. F. Morris

Research output: Contribution to journalArticle

74 Citations (Scopus)

Abstract

Transcriptional regulators control much of hematopoiesis. One such transcriptional regulator is the myeloid zinc finger gene MZF-1. MZF-1 has been localized to the telomere of chromosome 19q, where a large number of related zinc finger genes reside. It has been found to be essential in granulopoiesis. It is a bi-functional transcriptional regulator, repressing transcription in non-hematopoietic cells, and activating transcription in cells of hematopoietic origins. Its consensus DNA binding site has been isolated, and sites in several promoters of myeloid-specific genes, such as CD34, lactoferrin, and myeloperoxidase, have been defined. In co-transfection experiments MZF-1 has been found to regulate transcription from the CD34 promoter.

Original languageEnglish
Pages (from-to)158-164
Number of pages7
JournalCurrent Topics in Microbiology and Immunology
Volume211
StatePublished - 1996

Fingerprint

Zinc Fingers
Genes
Lactoferrin
Telomere
Hematopoiesis
Peroxidase
Transfection
Chromosomes
Binding Sites
DNA

ASJC Scopus subject areas

  • Immunology and Allergy
  • Microbiology (medical)
  • Immunology and Microbiology(all)
  • Microbiology

Cite this

Hromas, R., Davis, B., Rauscher, F. J., Klemsz, M., Tenen, D., Hoffman, S., ... Morris, J. F. (1996). Hematopoietic transcriptional regulation by the myeloid zinc finger gene, MZF-1. Current Topics in Microbiology and Immunology, 211, 158-164.

Hematopoietic transcriptional regulation by the myeloid zinc finger gene, MZF-1. / Hromas, R.; Davis, B.; Rauscher, F. J.; Klemsz, Michael; Tenen, D.; Hoffman, S.; Xu, Dawei; Morris, J. F.

In: Current Topics in Microbiology and Immunology, Vol. 211, 1996, p. 158-164.

Research output: Contribution to journalArticle

Hromas, R, Davis, B, Rauscher, FJ, Klemsz, M, Tenen, D, Hoffman, S, Xu, D & Morris, JF 1996, 'Hematopoietic transcriptional regulation by the myeloid zinc finger gene, MZF-1', Current Topics in Microbiology and Immunology, vol. 211, pp. 158-164.
Hromas, R. ; Davis, B. ; Rauscher, F. J. ; Klemsz, Michael ; Tenen, D. ; Hoffman, S. ; Xu, Dawei ; Morris, J. F. / Hematopoietic transcriptional regulation by the myeloid zinc finger gene, MZF-1. In: Current Topics in Microbiology and Immunology. 1996 ; Vol. 211. pp. 158-164.
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