Hemoglobins A and A2 in New World primates: Comparative variation and its evolutionary implications

Samuel H. Boyer, Emilio F. Crosby, Theodore F. Thurmon, Andrea N. Noyes, Gail F. Fuller, Sanford E. Leslie, Marguerite Shepard, C. Nash Herndon

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Hemoglobin A22δ2) in New World primates represents about 1/160 to 1/16 of total hemoglobin and, by virtue of this low proportion, is presumed to be functionally unimportant. Nonetheless, A2 exhibits genetic polymorphism by electrophoresis in three out of five genera, whereas the major component, hemoglobin A (α2β2), is electrophoretically invariant. Moreover, in four genera, including man, the evolutionary accumulation of mutations has been greater in δ than in β. Such findings suggest that both polymorphism and evolutionary changes can accrue to an effectively functionless and thus selectively nearly neutral gene.

Original languageEnglish (US)
Pages (from-to)1428-1431
Number of pages4
JournalScience
Volume166
Issue number3911
StatePublished - 1969
Externally publishedYes

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Hemoglobin A2
Hemoglobin A
Genetic Polymorphisms
varespladib methyl
Primates
Electrophoresis
Hemoglobins
Genes
Mutation Accumulation

ASJC Scopus subject areas

  • General

Cite this

Boyer, S. H., Crosby, E. F., Thurmon, T. F., Noyes, A. N., Fuller, G. F., Leslie, S. E., ... Herndon, C. N. (1969). Hemoglobins A and A2 in New World primates: Comparative variation and its evolutionary implications. Science, 166(3911), 1428-1431.

Hemoglobins A and A2 in New World primates : Comparative variation and its evolutionary implications. / Boyer, Samuel H.; Crosby, Emilio F.; Thurmon, Theodore F.; Noyes, Andrea N.; Fuller, Gail F.; Leslie, Sanford E.; Shepard, Marguerite; Herndon, C. Nash.

In: Science, Vol. 166, No. 3911, 1969, p. 1428-1431.

Research output: Contribution to journalArticle

Boyer, SH, Crosby, EF, Thurmon, TF, Noyes, AN, Fuller, GF, Leslie, SE, Shepard, M & Herndon, CN 1969, 'Hemoglobins A and A2 in New World primates: Comparative variation and its evolutionary implications', Science, vol. 166, no. 3911, pp. 1428-1431.
Boyer SH, Crosby EF, Thurmon TF, Noyes AN, Fuller GF, Leslie SE et al. Hemoglobins A and A2 in New World primates: Comparative variation and its evolutionary implications. Science. 1969;166(3911):1428-1431.
Boyer, Samuel H. ; Crosby, Emilio F. ; Thurmon, Theodore F. ; Noyes, Andrea N. ; Fuller, Gail F. ; Leslie, Sanford E. ; Shepard, Marguerite ; Herndon, C. Nash. / Hemoglobins A and A2 in New World primates : Comparative variation and its evolutionary implications. In: Science. 1969 ; Vol. 166, No. 3911. pp. 1428-1431.
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