Hepatic arterial buffer response

pathologic evidence in non-cirrhotic human liver with extrahepatic portal vein thrombosis

Natalia Rush, Hongliu Sun, Yukihiro Nakanishi, Wadad Mneimneh, Paul Y. Kwo, Romil Saxena

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Increase in hepatic arterial flow in response to reduced portal flow (hepatic arterial buffer response) has been demonstrated experimentally and surgically. We provide pathologic evidence for hepatic arterial buffer response in non-cirrhotic patients with extrahepatic portal vein thrombosis and elucidate the histopathologic spectrum of non-cirrhotic portal vein thrombosis. Liver biopsies and resections from non-cirrhotic patients with extra-hepatic portal vein thrombosis were retrieved. Morphologic features, extent of CD34 staining, outer diameters, luminal diameters and wall thickness of hepatic arteries cut in cross-section and outer diameters of cross-sectioned paired bile ducts were compared with age- and gender-matched controls. There were 12 male and 9 female patients. Measurements of 280 and 193 arteries from patients and controls, respectively, demonstrated statistically significant (P

Original languageEnglish (US)
JournalModern Pathology
DOIs
StateAccepted/In press - Feb 26 2016

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Portal Vein
Buffers
Thrombosis
Liver
Budd-Chiari Syndrome
Hepatic Artery
Bile Ducts
Arteries
Staining and Labeling
Biopsy

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Hepatic arterial buffer response : pathologic evidence in non-cirrhotic human liver with extrahepatic portal vein thrombosis. / Rush, Natalia; Sun, Hongliu; Nakanishi, Yukihiro; Mneimneh, Wadad; Kwo, Paul Y.; Saxena, Romil.

In: Modern Pathology, 26.02.2016.

Research output: Contribution to journalArticle

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