Hepatic biotransformation in lean and obese wistar kyoto rats: Comparison to that in streptozotocin-pretreated sprague-dawley rats

John B. Watkins, Lori A. Mangels

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1. Phase I and phase II biotransformation was compared in streptozotocin-induced hypo-insulinemic (STZ) and genetic hyperinsulinemic (WKY-fatty) rats. 2. Total cytochrome P-450 concentrations were reduced in both STZ and WKY, whereas styrene oxide hydrolase and benzphetamine N-demethylase activities were normal in STZ and reduced in WKY. 3. UDP-glucuronosyltransferase activity was decreased toward testosterone and 1-naphthol in STZ and WKY, and was increased toward estrone in the obese female WKY. 4. Glutathione S-transferase activity was decreased in STZ toward 1-chloro-2,4-dinitrobenzene, ethacrynic acid and sulfobromophthalein, but was similar to that in normal rats for WKY.

Original languageEnglish (US)
Pages (from-to)159-164
Number of pages6
JournalComparative Biochemistry and Physiology. Part C, Comparative
Issue number1
StatePublished - 1987


ASJC Scopus subject areas

  • Immunology
  • Pharmacology

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