Hepatic phase II biotransformation in C57Bl/KsJ db/db mice: comparison to that in swiss webster and 129 REJ mice

J. B. Watkins, K. M. klueber

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

1. 1. Cytochrome P-450 concentrations were similar in male and female carrier (db/+) and diabetic (db/db) mice. Benzphetamine N-demethylase and styrene oxide hydrolase activities were 47 and 65% lower in b/+ than in db/db mice. 2. 2. UDP-Glucuronosyltransferase activity toward 1-naphthol, estrone and diethylstilbestrol was not different between db/db and db/+ but was 40% higher in db/db mice toward testosterone. 3. 3. Glutathione S-transferase activity toward 1-chloro-2,4-dinitrobenzene and ethacrynic acid was 47 and 59% lower in db/db mice than in male db/+ mice. Female db/+ mice had similar activities to those found in diabetic animals. 4. 4. The differences in enzyme activity between hyperinsulinemic and normal animals suggest that insulin can influence both phase I and phase II biotransformations. 5. 5. Enzyme activities in db/+ and db/db mice were compared to those in 129 REJ and Swiss Webster mice.

Original languageEnglish (US)
Pages (from-to)417-421
Number of pages5
JournalComparative Biochemistry and Physiology. Part C, Comparative
Volume90
Issue number2
DOIs
StatePublished - 1988

ASJC Scopus subject areas

  • Immunology
  • Pharmacology

Fingerprint Dive into the research topics of 'Hepatic phase II biotransformation in C57Bl/KsJ db/db mice: comparison to that in swiss webster and 129 REJ mice'. Together they form a unique fingerprint.

  • Cite this