Hepatic protein pattern alterations following perfluorodecanoic acid exposure in rats

F. A. Witzmann, D. N. Parker

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

The effect after 8 days of 20 and 50 mg/kg in vivo exposure to perfluoro-n-decanoic acid (PFDA) on the protein pattern of rat liver whole homogenates was studied using high-resolution, large-scale two-dimensional polyacrylamide gel electrophoresis. PFDA exposure altered 13 proteins reproducibly in each of 5 samples tested. While most of the altered proteins remained unidentified, several known mitochondrial proteins were induced by PFDA as were others in a dose-related manner. Conversely, PFDA caused the reduction of albumin as well as several unknown proteins, also in a dose-related manner. Cytoskeletal proteins were unaffected by PFDA. The present results suggest that PFDA's toxic mechanism may involve more than membrane integration and lipid accumulation. Changes in the two-dimensional protein pattern indicate that selective protein synthetic or catabolic processes may undergo qualitative alterations after PFDA treatment as well.

Original languageEnglish (US)
Pages (from-to)29-36
Number of pages8
JournalToxicology Letters
Volume57
Issue number1
DOIs
StatePublished - Jun 1991

Keywords

  • Perfluorochemical toxicity
  • Two-dimensional polyacrylamide gel electrophoresis
  • Whole homogenates

ASJC Scopus subject areas

  • Toxicology

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