Hepatitis C increases the risk of progression of chronic kidney disease in patients with glomerulonephritis

Lama A. Noureddine, Sohail A. Usman, Zhangsheng Yu, Ranjani N. Moorthi, Sharon M. Moe

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

Background/Aims: We have shown that hepatitis C does not increase the risk of developing chronic kidney disease (CKD), but it is not known if hepatitis C worsens progression of existing CKD. Methods: We retrospectively identified patients with primary glomerulonephritis on biopsy over 4 years, evaluating the progression of CKD over time. Results: The cohort consisted of 111 patients: 21% were positive for hepatitis C, 61% were negative for hepatitis C and 18% were not tested. The hepatitis C-positive subjects were more likely to be African American (p = 0.031), followed for fewer days (p = 0.007) and have diabetes and focal segmental glomerulosclerosis on biopsy (p < 0.001). Longitudinal follow-up of CKD progression using multiple creatinine measures analyzed by repeated measures ANCOVA demonstrated that patients with hepatitis C had a worsening creatinine over time compared to the hepatitis C-negative and not tested groups (p < 0.001). By Cox hazards regression analyses, risk of death/end-stage renal disease (ESRD) was decreased in patients who tested negative for hepatitis C compared to testing positive (0.46, CI 0.27-0.88), but this became nonsignificant after adjustment for mean arterial pressure and hemoglobin. Conclusion: Our results support that infection with hepatitis C in patients with glomerulonephritis is associated with an increased risk of progression of CKD. Prospective studies are required to confirm these observations.

Original languageEnglish (US)
Pages (from-to)311-316
Number of pages6
JournalAmerican journal of nephrology
Volume32
Issue number4
DOIs
StatePublished - Oct 1 2010

Keywords

  • Chronic kidney disease
  • Diabetic nephropathy
  • Dialysis
  • Focal segmental glomerulosclerosis
  • Glomerulonephritis
  • Hepatitis C

ASJC Scopus subject areas

  • Nephrology

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