Hepatitis C virus does not cause nonalcoholic steatohepatitis

D. W. Rogers, C. H. Lee, D. C. Pound, S. Kumar, O. W. Cummings, L. Lumeng

Research output: Contribution to journalArticle

20 Scopus citations


The pathogenesis of nonalcoholic steatohepatitis (NASH) remains poorly understood. Since inflammation and fatty changes are associated with hepatitis C (HCV) infection, we have tested the role of HCV in the genesis of NASH. Five consecutive cases of classic NASH were tested by Abbott anti-c100-3 EIA and polymerase chain reaction (PCR) to detect HCV-RNA. All serum specimens were negative for anti-c100-3 (or anti-HCV EIA) and HCV PCR. Based on this study, we conclude that HCV does not play a causative or contributing role in the pathogenesis of NASH.

Original languageEnglish (US)
Pages (from-to)1644-1647
Number of pages4
JournalDigestive diseases and sciences
Issue number11
StatePublished - Nov 1 1992


  • anti-c100-3 EIA
  • hepatitis C virus
  • Nonalcoholic steatohepatitis
  • polymerase chain reaction

ASJC Scopus subject areas

  • Gastroenterology

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    Rogers, D. W., Lee, C. H., Pound, D. C., Kumar, S., Cummings, O. W., & Lumeng, L. (1992). Hepatitis C virus does not cause nonalcoholic steatohepatitis. Digestive diseases and sciences, 37(11), 1644-1647. https://doi.org/10.1007/BF01299852