Hepatitis C virus does not cause nonalcoholic steatohepatitis

D. W. Rogers, Chao-Hung Lee, D. C. Pound, S. Kumar, Oscar Cummings, L. Lumeng

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The pathogenesis of nonalcoholic steatohepatitis (NASH) remains poorly understood. Since inflammation and fatty changes are associated with hepatitis C (HCV) infection, we have tested the role of HCV in the genesis of NASH. Five consecutive cases of classic NASH were tested by Abbott anti-c100-3 EIA and polymerase chain reaction (PCR) to detect HCV-RNA. All serum specimens were negative for anti-c100-3 (or anti-HCV EIA) and HCV PCR. Based on this study, we conclude that HCV does not play a causative or contributing role in the pathogenesis of NASH.

Original languageEnglish
Pages (from-to)1644-1647
Number of pages4
JournalDigestive Diseases and Sciences
Volume37
Issue number11
DOIs
StatePublished - Nov 1992

Fingerprint

Hepacivirus
Polymerase Chain Reaction
Hepatitis C
RNA
Inflammation
Non-alcoholic Fatty Liver Disease
Infection
Serum
anti-C100-3

Keywords

  • anti-c100-3 EIA
  • hepatitis C virus
  • Nonalcoholic steatohepatitis
  • polymerase chain reaction

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Hepatitis C virus does not cause nonalcoholic steatohepatitis. / Rogers, D. W.; Lee, Chao-Hung; Pound, D. C.; Kumar, S.; Cummings, Oscar; Lumeng, L.

In: Digestive Diseases and Sciences, Vol. 37, No. 11, 11.1992, p. 1644-1647.

Research output: Contribution to journalArticle

Rogers, D. W. ; Lee, Chao-Hung ; Pound, D. C. ; Kumar, S. ; Cummings, Oscar ; Lumeng, L. / Hepatitis C virus does not cause nonalcoholic steatohepatitis. In: Digestive Diseases and Sciences. 1992 ; Vol. 37, No. 11. pp. 1644-1647.
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