Hepato-biliary late effects in survivors of childhood and adolescent cancer: A report from the Children's Oncology Group

Sharon Castellino, Andrew Muir, Ami Shah, Sheila Shope, Kevin McMullen, Kathy Ruble, Ashley Barber, Andrew Davidoff, Melissa M. Hudson

Research output: Contribution to journalReview article

35 Scopus citations

Abstract

Curative therapy for childhood and adolescent cancer translates to 1 in 640 young adults being a survivor of cancer. Although acute hepato-biliary toxicity occurs commonly during pediatric cancer therapy, the impact of antineoplastic therapy on long-term liver health in childhood/adolescent cancer survivors is unknown. This article reviews the medical literature on late liver dysfunction following treatment for childhood/adolescent cancer. We also outline the Children's Oncology Group (COG) guidelines for screening and follow-up of hepato-biliary sequelae. As the population of survivors grow and age, vigilance for risks to hepatic health needs to continue based on specific exposures during curative cancer therapy.

Original languageEnglish (US)
Pages (from-to)663-669
Number of pages7
JournalPediatric Blood and Cancer
Volume54
Issue number5
DOIs
StatePublished - May 1 2010

Keywords

  • Adolescent cancer survivor
  • Childhood cancer
  • Hepato-biliary late effects
  • Screening

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

Fingerprint Dive into the research topics of 'Hepato-biliary late effects in survivors of childhood and adolescent cancer: A report from the Children's Oncology Group'. Together they form a unique fingerprint.

  • Cite this

    Castellino, S., Muir, A., Shah, A., Shope, S., McMullen, K., Ruble, K., Barber, A., Davidoff, A., & Hudson, M. M. (2010). Hepato-biliary late effects in survivors of childhood and adolescent cancer: A report from the Children's Oncology Group. Pediatric Blood and Cancer, 54(5), 663-669. https://doi.org/10.1002/pbc.22265