Hepatobiliary disease in sarcoidosis

Charles Kahi, Romil Saxena, M'Hamid Temkit, Karen Canlas, Scott Roberts, Kenneth Knox, David Wilkes, Paul Y. Kwo

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Background and Aim: Sarcoidosis is a multisystem granulomatous disease of unknown etiology. Little is known about the prevalence, pattern, and risk factors for hepatobiliary disease in patients with sarcoidosis. Methods: We retrieved the records of all patients diagnosed with sarcoidosis at a tertiary care referral hospital and a county hospital between 1976 and 2002. Liver disease was defined as abnormal liver tests (AST > 45 U/L, ALT > 35 U/L, alkaline phosphatase > 125 U/L, total bilirubin > 1.3 mg/dL) in the setting of sarcoidosis. Patients with sarcoidosis and normal liver tests constituted a comparison group. Results: A total of 1,436 patients with presumed sarcoidosis were identified (66% female, 57% African-American). Three hundred and forty patients had abnormalities in liver tests, and 40 with confirmed sarcoidosis underwent a liver biopsy. Biopsy specimens were available for review for 34 patients; 29 (85%) of 34 exhibited various degrees of portal inflammation, bile duct depletion was noted in 17 (50%), and 9 (26%) had bridging fibrosis or cirrhosis. One hundred and thirty patients with sarcoidosis and normal liver tests were compared to the 40 with sarcoid-related hepatic dysfunction. Male gender, hepatomegaly, splenomegaly, and normal chest radiograph were associated with hepatic sarcoidosis. On multivariate analysis, male gender (OR 2.8, p = 0.012), and splenomegaly (OR 9.2, p < 0.0001) were more prevalent in the group with liver disease. Conclusions: Hepatobiliary disease in sarcoidosis is rarely clinically overt. When present, it ranges from asymptomatic liver tests abnormalities to cirrhosis. Male gender and splenomegaly were significantly associated with sarcoid-related liver disease.

Original languageEnglish
Pages (from-to)117-123
Number of pages7
JournalSarcoidosis Vasculitis and Diffuse Lung Diseases
Volume23
Issue number2
StatePublished - Jun 2006

Fingerprint

Sarcoidosis
Liver
Splenomegaly
Liver Diseases
Fibrosis
Biopsy
County Hospitals
Hepatomegaly
Tertiary Healthcare
Bile Ducts
Bilirubin
Tertiary Care Centers
African Americans
Alkaline Phosphatase
Thorax
Multivariate Analysis
Inflammation

Keywords

  • Hepatobiliary sarcoidosis
  • Liver sarcoidosis
  • Liver tests in sarcoidosis

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Kahi, C., Saxena, R., Temkit, MH., Canlas, K., Roberts, S., Knox, K., ... Kwo, P. Y. (2006). Hepatobiliary disease in sarcoidosis. Sarcoidosis Vasculitis and Diffuse Lung Diseases, 23(2), 117-123.

Hepatobiliary disease in sarcoidosis. / Kahi, Charles; Saxena, Romil; Temkit, M'Hamid; Canlas, Karen; Roberts, Scott; Knox, Kenneth; Wilkes, David; Kwo, Paul Y.

In: Sarcoidosis Vasculitis and Diffuse Lung Diseases, Vol. 23, No. 2, 06.2006, p. 117-123.

Research output: Contribution to journalArticle

Kahi, C, Saxena, R, Temkit, MH, Canlas, K, Roberts, S, Knox, K, Wilkes, D & Kwo, PY 2006, 'Hepatobiliary disease in sarcoidosis', Sarcoidosis Vasculitis and Diffuse Lung Diseases, vol. 23, no. 2, pp. 117-123.
Kahi C, Saxena R, Temkit MH, Canlas K, Roberts S, Knox K et al. Hepatobiliary disease in sarcoidosis. Sarcoidosis Vasculitis and Diffuse Lung Diseases. 2006 Jun;23(2):117-123.
Kahi, Charles ; Saxena, Romil ; Temkit, M'Hamid ; Canlas, Karen ; Roberts, Scott ; Knox, Kenneth ; Wilkes, David ; Kwo, Paul Y. / Hepatobiliary disease in sarcoidosis. In: Sarcoidosis Vasculitis and Diffuse Lung Diseases. 2006 ; Vol. 23, No. 2. pp. 117-123.
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