Hepatobiliary excretion of cysteinyl leukotrienes in three experimental models of acute hepatic injury

H. M. Omar, R. A. Sanders, J. B. Watkins

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The acute phase response to chemically-induced or an damage involves inflammation and the production of leukotrienes. The liver ordinarily takes up, metabolizes and excretes into bile cysteinyl leukotrienes, but the effect of hepatic injury on these processes is unknown. The hepatic uptake and biliary excretion of LTC4 was studied in male Sprague-Dawley rats after exposure to either streptozotocin (45 mg/kgiv 30 days before experimentation), estradiol-17β-valerate (1 mg/kg sc once a week for 3 weeks) or lipopolysaccharide/D-galactosamine (33 μg/kgip; 300 mg/kgip at 6 h and 3 h, respectively, before experimentation). Acute liver injury is produced by these treatment paradigms. Glucose concentrations and activities of several marker enzymes in plasma were measured to demonstrate hepatic injury. Biliary excretion of 3H-LTC4 was similar to normal control rats in the three types of acute liver injury. Bile flow rates after 3H-LTC4 injection were reduced in lipopolysaccharide-pretreated rats and increased in estradiol-treated animals. Total biliary excretion of leukotrienes was not altered in any disease group. Thus, these models of acute hepatic injury do not appear to influence the hepatobiliary clearance of leukotrienes.

Original languageEnglish
Pages (from-to)519-523
Number of pages5
JournalInflammation Research
Volume45
Issue number10
DOIs
StatePublished - 1996

Fingerprint

Leukotriene C4
Leukotrienes
Theoretical Models
Liver
Wounds and Injuries
Lipopolysaccharides
Rats
Estradiol
estradiol valerate
Rat control
Valerates
Bile
Galactosamine
Streptozocin
Acute-Phase Reaction
Animals
Flow rate
Plasmas
Glucose
Sprague Dawley Rats

Keywords

  • Estradiol
  • Galactosamine
  • Leukotrienes
  • Lipopolysaccharide
  • Streptozotocin

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology (medical)
  • Immunology
  • Cell Biology

Cite this

Hepatobiliary excretion of cysteinyl leukotrienes in three experimental models of acute hepatic injury. / Omar, H. M.; Sanders, R. A.; Watkins, J. B.

In: Inflammation Research, Vol. 45, No. 10, 1996, p. 519-523.

Research output: Contribution to journalArticle

Omar, H. M. ; Sanders, R. A. ; Watkins, J. B. / Hepatobiliary excretion of cysteinyl leukotrienes in three experimental models of acute hepatic injury. In: Inflammation Research. 1996 ; Vol. 45, No. 10. pp. 519-523.
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