Hepatobiliary lymphoepithelioma-like carcinoma associated with Epstein- Barr virus

Alexander Vortmeyer, Douglas W. Kingma, Robert G. Fenton, Brendan D. Curti, Elaine S. Jaffe, Paul H. Duray

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

We describe the clinical and pathologic features of a lymphoepithelioma- like carcinoma (LELC) that originated in the hepatobiliary system. A woman, aged 71 years, was first seen with a noncholangiolar adenocarcinoma with lymphoid stroma, which was discovered by open liver biopsy in 1993. In 1995, retroperitoneal and peripancreatic lymph nodes were involved by LELC. There currently is no evidence of distant metastasis outside the hepatobiliary peripancreatic region. Review of the biopsy material revealed a well- differentiated adenocarcinoma with transition into LELC. Epstein-Barr virus (EBV) transcripts were expressed in all histologic phases of the tumor by in situ hybridization using immunoalkaline phosphatase-labeled oligonucleotide probes for EBV-encoded RNA 1 on formalin-fixed, paraffin-embedded sections. Polymerase chain reaction analysis for EBV nuclear antigen 2 was consistent with EBV strain type A. The LMP-1 gene was found to be wild type by polymerase chain reaction analysis. To our knowledge, this is the first report of a primary hepatobiliary adenocarcinoma associated with EBV infection that transformed into an undifferentiated LELC.

Original languageEnglish (US)
Pages (from-to)90-95
Number of pages6
JournalAmerican Journal of Clinical Pathology
Volume109
Issue number1
DOIs
StatePublished - Jan 1 1998
Externally publishedYes

Fingerprint

Human Herpesvirus 4
Carcinoma
Adenocarcinoma
Epstein-Barr Virus Nuclear Antigens
Biopsy
Polymerase Chain Reaction
Epstein-Barr Virus Infections
Oligonucleotide Probes
Phosphoric Monoester Hydrolases
Paraffin
Formaldehyde
In Situ Hybridization
Lymph Nodes
Neoplasm Metastasis
Liver
Genes
Neoplasms

Keywords

  • Epstein-Barr virus
  • In situ hybridization
  • Lymphoepithelioma
  • Lymphoepithelioma-like carcinoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Hepatobiliary lymphoepithelioma-like carcinoma associated with Epstein- Barr virus. / Vortmeyer, Alexander; Kingma, Douglas W.; Fenton, Robert G.; Curti, Brendan D.; Jaffe, Elaine S.; Duray, Paul H.

In: American Journal of Clinical Pathology, Vol. 109, No. 1, 01.01.1998, p. 90-95.

Research output: Contribution to journalArticle

Vortmeyer, Alexander ; Kingma, Douglas W. ; Fenton, Robert G. ; Curti, Brendan D. ; Jaffe, Elaine S. ; Duray, Paul H. / Hepatobiliary lymphoepithelioma-like carcinoma associated with Epstein- Barr virus. In: American Journal of Clinical Pathology. 1998 ; Vol. 109, No. 1. pp. 90-95.
@article{65e0e2c21ec84db59caa12473d6d0b2f,
title = "Hepatobiliary lymphoepithelioma-like carcinoma associated with Epstein- Barr virus",
abstract = "We describe the clinical and pathologic features of a lymphoepithelioma- like carcinoma (LELC) that originated in the hepatobiliary system. A woman, aged 71 years, was first seen with a noncholangiolar adenocarcinoma with lymphoid stroma, which was discovered by open liver biopsy in 1993. In 1995, retroperitoneal and peripancreatic lymph nodes were involved by LELC. There currently is no evidence of distant metastasis outside the hepatobiliary peripancreatic region. Review of the biopsy material revealed a well- differentiated adenocarcinoma with transition into LELC. Epstein-Barr virus (EBV) transcripts were expressed in all histologic phases of the tumor by in situ hybridization using immunoalkaline phosphatase-labeled oligonucleotide probes for EBV-encoded RNA 1 on formalin-fixed, paraffin-embedded sections. Polymerase chain reaction analysis for EBV nuclear antigen 2 was consistent with EBV strain type A. The LMP-1 gene was found to be wild type by polymerase chain reaction analysis. To our knowledge, this is the first report of a primary hepatobiliary adenocarcinoma associated with EBV infection that transformed into an undifferentiated LELC.",
keywords = "Epstein-Barr virus, In situ hybridization, Lymphoepithelioma, Lymphoepithelioma-like carcinoma",
author = "Alexander Vortmeyer and Kingma, {Douglas W.} and Fenton, {Robert G.} and Curti, {Brendan D.} and Jaffe, {Elaine S.} and Duray, {Paul H.}",
year = "1998",
month = "1",
day = "1",
doi = "10.1093/ajcp/109.1.90",
language = "English (US)",
volume = "109",
pages = "90--95",
journal = "American Journal of Clinical Pathology",
issn = "0002-9173",
publisher = "American Society of Clinical Pathologists",
number = "1",

}

TY - JOUR

T1 - Hepatobiliary lymphoepithelioma-like carcinoma associated with Epstein- Barr virus

AU - Vortmeyer, Alexander

AU - Kingma, Douglas W.

AU - Fenton, Robert G.

AU - Curti, Brendan D.

AU - Jaffe, Elaine S.

AU - Duray, Paul H.

PY - 1998/1/1

Y1 - 1998/1/1

N2 - We describe the clinical and pathologic features of a lymphoepithelioma- like carcinoma (LELC) that originated in the hepatobiliary system. A woman, aged 71 years, was first seen with a noncholangiolar adenocarcinoma with lymphoid stroma, which was discovered by open liver biopsy in 1993. In 1995, retroperitoneal and peripancreatic lymph nodes were involved by LELC. There currently is no evidence of distant metastasis outside the hepatobiliary peripancreatic region. Review of the biopsy material revealed a well- differentiated adenocarcinoma with transition into LELC. Epstein-Barr virus (EBV) transcripts were expressed in all histologic phases of the tumor by in situ hybridization using immunoalkaline phosphatase-labeled oligonucleotide probes for EBV-encoded RNA 1 on formalin-fixed, paraffin-embedded sections. Polymerase chain reaction analysis for EBV nuclear antigen 2 was consistent with EBV strain type A. The LMP-1 gene was found to be wild type by polymerase chain reaction analysis. To our knowledge, this is the first report of a primary hepatobiliary adenocarcinoma associated with EBV infection that transformed into an undifferentiated LELC.

AB - We describe the clinical and pathologic features of a lymphoepithelioma- like carcinoma (LELC) that originated in the hepatobiliary system. A woman, aged 71 years, was first seen with a noncholangiolar adenocarcinoma with lymphoid stroma, which was discovered by open liver biopsy in 1993. In 1995, retroperitoneal and peripancreatic lymph nodes were involved by LELC. There currently is no evidence of distant metastasis outside the hepatobiliary peripancreatic region. Review of the biopsy material revealed a well- differentiated adenocarcinoma with transition into LELC. Epstein-Barr virus (EBV) transcripts were expressed in all histologic phases of the tumor by in situ hybridization using immunoalkaline phosphatase-labeled oligonucleotide probes for EBV-encoded RNA 1 on formalin-fixed, paraffin-embedded sections. Polymerase chain reaction analysis for EBV nuclear antigen 2 was consistent with EBV strain type A. The LMP-1 gene was found to be wild type by polymerase chain reaction analysis. To our knowledge, this is the first report of a primary hepatobiliary adenocarcinoma associated with EBV infection that transformed into an undifferentiated LELC.

KW - Epstein-Barr virus

KW - In situ hybridization

KW - Lymphoepithelioma

KW - Lymphoepithelioma-like carcinoma

UR - http://www.scopus.com/inward/record.url?scp=0031963250&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031963250&partnerID=8YFLogxK

U2 - 10.1093/ajcp/109.1.90

DO - 10.1093/ajcp/109.1.90

M3 - Article

VL - 109

SP - 90

EP - 95

JO - American Journal of Clinical Pathology

JF - American Journal of Clinical Pathology

SN - 0002-9173

IS - 1

ER -