Hepatoblastoma

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Hepatoblastoma is the most common primary malignant hepatic tumor of infancy and childhood, occurring predominantly in the first two years of life. The management of hepatoblastoma has changed markedly over the last 3 decades; neoadjuvant chemotherapy is now standard, particularly in unresectable tumors resulting in considerable preoperative tumor shrinkage and sometimes near total ablation of the tumor. A 20 month old infant was incidentally found to have a 7.6. cm right sided retroperitoneal tumor on routine screening ultrasonography for left ureteral stenosis. Serum alpha fetoprotein was elevated. Biopsy revealed hepatoblastoma, mixed epithelial and embryonal type without mesenchymal elements. He underwent neoadjuvant chemotherapy. Although the tumor had decreased considerably in size, close proximity to major vascular structures precluded safe resection. Liver transplantation was performed; the explanted liver showed complete tumor necrosis with no residual malignancy. The postoperative course was uncomplicated and he is continuing on sixth cycle of chemotherapy.

Original languageEnglish (US)
JournalSeminars in Diagnostic Pathology
DOIs
StateAccepted/In press - 2017

Fingerprint

Hepatoblastoma
Neoplasms
Drug Therapy
Liver
alpha-Fetoproteins
Liver Transplantation
Blood Vessels
Ultrasonography
Pathologic Constriction
Necrosis
Biopsy

Keywords

  • Mixed epithelial mesenchymal hepatoblastoma
  • Pure fetal hepatoblastoma
  • Small cell undifferentiated hepatoblastoma
  • Teratoid hepatoblastoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medicine(all)

Cite this

Hepatoblastoma. / Sharma, Divya; Subbarao, Girish; Saxena, Romil.

In: Seminars in Diagnostic Pathology, 2017.

Research output: Contribution to journalArticle

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