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27 Scopus citations


Hepatoblastoma is the most common primary malignant hepatic tumor of infancy and childhood, occurring predominantly in the first two years of life. The management of hepatoblastoma has changed markedly over the last 3 decades; neoadjuvant chemotherapy is now standard, particularly in unresectable tumors resulting in considerable preoperative tumor shrinkage and sometimes near total ablation of the tumor. A 20 month old infant was incidentally found to have a 7.6 cm right sided retroperitoneal tumor on routine screening ultrasonography for left ureteral stenosis. Serum alpha fetoprotein was elevated. Biopsy revealed hepatoblastoma, mixed epithelial and embryonal type without mesenchymal elements. He underwent neoadjuvant chemotherapy. Although the tumor had decreased considerably in size, close proximity to major vascular structures precluded safe resection. Liver transplantation was performed; the explanted liver showed complete tumor necrosis with no residual malignancy. The postoperative course was uncomplicated and he is continuing on sixth cycle of chemotherapy.

Original languageEnglish (US)
Pages (from-to)192-200
Number of pages9
JournalSeminars in Diagnostic Pathology
Issue number2
StatePublished - Mar 1 2017


  • Mixed epithelial mesenchymal hepatoblastoma
  • Pure fetal hepatoblastoma
  • Small cell undifferentiated hepatoblastoma
  • Teratoid hepatoblastoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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