Hereditary amyloidosis: Description of a new American kindred with late onset cardiomyopathy. Appalachian amyloid

Merrill Benson, M. R. Wallace, E. Tejada, H. Baumann, B. Page

Research output: Contribution to journalArticle

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Abstract

A family with hereditary amyloidosis characterized by peripheral neuropathy and cardiomyopathy is described. Lack of eye involvement sets their disease apart from the Indiana/Swiss familial amyloidotic polyneuropathy type II. The disease is of late onset; affected members die of cardiomyopathy after age 60. The late onset and lack of clinically significant neuropathy in several family members had led to misdiagnosis of the cardiomyopathy. Immunohistochemistry using antiprealbumin antiserum showed staining of amyloid deposits in nerve and heart.

Original languageEnglish
Pages (from-to)195-200
Number of pages6
JournalArthritis and Rheumatism
Volume30
Issue number2
DOIs
StatePublished - 1987

Fingerprint

Familial Amyloidosis
Cardiomyopathies
Amyloid
Polyneuropathies
Amyloid Plaques
Peripheral Nervous System Diseases
Diagnostic Errors
Immune Sera
Immunohistochemistry
Staining and Labeling

ASJC Scopus subject areas

  • Immunology
  • Rheumatology

Cite this

Hereditary amyloidosis : Description of a new American kindred with late onset cardiomyopathy. Appalachian amyloid. / Benson, Merrill; Wallace, M. R.; Tejada, E.; Baumann, H.; Page, B.

In: Arthritis and Rheumatism, Vol. 30, No. 2, 1987, p. 195-200.

Research output: Contribution to journalArticle

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