Hereditary amyloidosis: Evidence against early amyloid deposition

Noam Harats, Robert M. Worth, Merrill D. Benson

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Twelve members of the Indiana hereditary amyloidosis type II kindred were tested for the presence of amyloid deposits. All were young adults (age 26–37), with no evidence of disease and with 1 affected parent. Six were found to be carriers of the variant gene, by DNA testing and/or reduced serum retinol‐binding protein levels. Nevertheless, no amyloid could be found in any skin, rectal, or carpal tunnel biopsy specimens. Our results suggest that hereditary amyloidosis type II is a true late‐onset disease, in which accumulation of amyloid does not start until late in life—perhaps only a short time before symptoms appear.

Original languageEnglish (US)
Pages (from-to)1474-1476
Number of pages3
JournalArthritis & Rheumatism
Volume32
Issue number11
DOIs
StatePublished - Nov 1989

ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology
  • Pharmacology (medical)

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