Hereditary variations in monoamine oxidase as a risk factor for Parkinson's disease

G. S. Hotamisligil, A. S. Girmen, J. S. Fink, E. Tivol, C. Shalish, T. Trofatter, John Baenziger, S. Diamond, C. Markham, J. Sullivan, J. Growdon, X. O. Breakefield

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

Parkinson's disease (PD) is a common neurodegenerative disorder caused by loss of dopaminergic neurons in the brainstem. Recent studies suggest that several genes may have a role in determining individual susceptibility to this disease, and the degradative enzyme monoamine oxidase (MAO) has been implicated in the disease process. Wide differences in activity levels for both forms of this enzyme (MAO-A and MAO-B) exist in the human population, and levels of both are genetically determined. Here we have compared the frequency of haplotypes at the MAOA and MAOB loci on the X chromosome in 91 male patients with PD and 129 male controls. Alleles were marked using two restriction fragment length polymorphisms (RFLPs), a (GT)n repeat in the MAOA locus, and a (GT)n repeat in the MAOB locus. One particular haplotype marked by the RFLP's at MAOA was three times more frequent in patients with PD as compared with controls, and the overall distribution of these alleles was significantly different (p = 0.03) between these two groups. Another MAOA haplotype was about threefold more common in controls than in patients with PD (p = 0.005). No associations were observed between individual MAOB alleles and the disease state, but the frequency distribution for all alleles was significantly different in the two populations (p = 0.046). These findings support the idea that the MAO genes may be among the hereditary factors that influence susceptibility of individuals to PD.

Original languageEnglish (US)
Pages (from-to)305-310
Number of pages6
JournalMovement Disorders
Volume9
Issue number3
StatePublished - 1994

Fingerprint

Monoamine Oxidase
Parkinson Disease
Alleles
Haplotypes
Restriction Fragment Length Polymorphisms
Dopaminergic Neurons
Disease Susceptibility
X Chromosome
Enzymes
Neurodegenerative Diseases
Population
Genes
Brain Stem

Keywords

  • Monoamine oxidase
  • Parkinson's disease

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Hotamisligil, G. S., Girmen, A. S., Fink, J. S., Tivol, E., Shalish, C., Trofatter, T., ... Breakefield, X. O. (1994). Hereditary variations in monoamine oxidase as a risk factor for Parkinson's disease. Movement Disorders, 9(3), 305-310.

Hereditary variations in monoamine oxidase as a risk factor for Parkinson's disease. / Hotamisligil, G. S.; Girmen, A. S.; Fink, J. S.; Tivol, E.; Shalish, C.; Trofatter, T.; Baenziger, John; Diamond, S.; Markham, C.; Sullivan, J.; Growdon, J.; Breakefield, X. O.

In: Movement Disorders, Vol. 9, No. 3, 1994, p. 305-310.

Research output: Contribution to journalArticle

Hotamisligil, GS, Girmen, AS, Fink, JS, Tivol, E, Shalish, C, Trofatter, T, Baenziger, J, Diamond, S, Markham, C, Sullivan, J, Growdon, J & Breakefield, XO 1994, 'Hereditary variations in monoamine oxidase as a risk factor for Parkinson's disease', Movement Disorders, vol. 9, no. 3, pp. 305-310.
Hotamisligil GS, Girmen AS, Fink JS, Tivol E, Shalish C, Trofatter T et al. Hereditary variations in monoamine oxidase as a risk factor for Parkinson's disease. Movement Disorders. 1994;9(3):305-310.
Hotamisligil, G. S. ; Girmen, A. S. ; Fink, J. S. ; Tivol, E. ; Shalish, C. ; Trofatter, T. ; Baenziger, John ; Diamond, S. ; Markham, C. ; Sullivan, J. ; Growdon, J. ; Breakefield, X. O. / Hereditary variations in monoamine oxidase as a risk factor for Parkinson's disease. In: Movement Disorders. 1994 ; Vol. 9, No. 3. pp. 305-310.
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