Heritability and clinical features of multigenerational families with obsessive-compulsive disorder and hoarding

Carol A. Mathews, Caroline M. Nievergelt, Amin Azzam, Helena Garrido, Denise A. Chavira, Jennifer Wessel, Monica Bagnarello, Victor I. Reus, Nicholas J. Schork

Research output: Contribution to journalArticle

39 Scopus citations

Abstract

To date, only one complete genome screen for obsessive-compulsive disorder (OCD) has been published. That study identified a region of suggestive linkage (maximum lod score of 2.25) with a relatively small sample size (N = 56; 27 with OCD). Additional complete genome screens are needed to confirm this finding and identify other regions of linkage. We present the clinical characteristics and power to detect linkage of 11 multigenerational families with OCD and hoarding (N = 92; 44 with OCD), as well as heritability estimates for several quantitative traits. Families with at least two individuals with OCD were identified through probands with childhood-onset OCD. Expected lod scores were calculated for simulated genetic marker data under an additive and two dominant models assuming a dense SNP marker map. All affected individuals had an early age of onset (18 or younger). Hoarding was present in 46% of subjects. Obsessive-compulsive symptoms and hoarding were highly heritable. The maximum mean expected lod score was 3.31 for OCD and 1.39 for hoarding. We found reasonable power to detect regions of interest (lod = 2) for OCD in these families, but will need to expand our family collection to have adequate power to detect regions of interest for hoarding.

Original languageEnglish (US)
Pages (from-to)174-182
Number of pages9
JournalAmerican Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
Volume144
Issue number2
DOIs
StatePublished - Mar 5 2007

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Keywords

  • Genetics
  • Heritability
  • Hoarding
  • Obsessive-compulsive disorder
  • Quantitative trait

ASJC Scopus subject areas

  • Genetics(clinical)
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

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