Heritability of bipolar EEG spectra in a large sib-pair population

Yongqiang Tang, David B. Chorlian, Madhavi Rangaswamy, Sean O'Connor, Robert Taylor, John Rohrbaugh, Bernice Porjesz, Henri Begleiter

Research output: Contribution to journalArticle

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Abstract

The additive genetic heritability of both monopolar and bipolar EEG spectral power in a sample of 305 non-twin sibships comprising 690 individuals (age range 7-65) was estimated in order to investigate their regional variation. The heritabilities of the bipolar EEG spectral power ranged from 0.10 to 0.63 in 38 electrode-pairs, and those of monopolar power ranged from 0.23 to 0.68 in 19 electrodes in six frequency bands from theta to high beta. The bipolar data shows significantly greater topographic variation compared to that of the monopolar data. The mean of bivariate genetic correlations were consistently lower for the bipolar data and the coefficients of variation consistently higher when compared to those of the monopolar data for each of the frequency bands. The results from the bipolar derivations are in greater accord with genetic findings in brain anatomy and show the possibility of multiple genetic sources for the phenotypic variability of EEG activity.

Original languageEnglish
Pages (from-to)302-313
Number of pages12
JournalBehavior Genetics
Volume37
Issue number2
DOIs
StatePublished - Mar 2007

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heritability
Electroencephalography
electrodes
Electrodes
Population
electrode
genetic correlation
Anatomy
anatomy
brain
Brain
sampling

Keywords

  • Bipolar EEG spectra
  • Genetic correlation
  • Heritability
  • Sib-pair

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)
  • Behavioral Neuroscience
  • Psychology(all)

Cite this

Tang, Y., Chorlian, D. B., Rangaswamy, M., O'Connor, S., Taylor, R., Rohrbaugh, J., ... Begleiter, H. (2007). Heritability of bipolar EEG spectra in a large sib-pair population. Behavior Genetics, 37(2), 302-313. https://doi.org/10.1007/s10519-006-9133-0

Heritability of bipolar EEG spectra in a large sib-pair population. / Tang, Yongqiang; Chorlian, David B.; Rangaswamy, Madhavi; O'Connor, Sean; Taylor, Robert; Rohrbaugh, John; Porjesz, Bernice; Begleiter, Henri.

In: Behavior Genetics, Vol. 37, No. 2, 03.2007, p. 302-313.

Research output: Contribution to journalArticle

Tang, Y, Chorlian, DB, Rangaswamy, M, O'Connor, S, Taylor, R, Rohrbaugh, J, Porjesz, B & Begleiter, H 2007, 'Heritability of bipolar EEG spectra in a large sib-pair population', Behavior Genetics, vol. 37, no. 2, pp. 302-313. https://doi.org/10.1007/s10519-006-9133-0
Tang Y, Chorlian DB, Rangaswamy M, O'Connor S, Taylor R, Rohrbaugh J et al. Heritability of bipolar EEG spectra in a large sib-pair population. Behavior Genetics. 2007 Mar;37(2):302-313. https://doi.org/10.1007/s10519-006-9133-0
Tang, Yongqiang ; Chorlian, David B. ; Rangaswamy, Madhavi ; O'Connor, Sean ; Taylor, Robert ; Rohrbaugh, John ; Porjesz, Bernice ; Begleiter, Henri. / Heritability of bipolar EEG spectra in a large sib-pair population. In: Behavior Genetics. 2007 ; Vol. 37, No. 2. pp. 302-313.
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