Heritable one-hit events defining cancer prevention?

Levy Kopelovich, Brittney Shea-Herbert

Research output: Contribution to journalArticle

8 Scopus citations


Over 100 years ago (1902-1914) Theodor Boveri suggested a role for mutations in cancer.1,2 Boveri's ideas were derived from the then "just-emerging" chromosome theory of inheritance. While demonstrating chromosomal aberrations as a cause of genetic imbalance, Boveri suggested that possible causes of malignancy may include events such as aneuploidy that are now defined as gene mutations, asserting all the while that malignancy occurs at the cellular level. Indeed, studies to date essentially uniformly show that cancer is a genetic disease.

Original languageEnglish (US)
Pages (from-to)2553-2557
Number of pages5
JournalCell Cycle
Issue number16
StatePublished - Aug 15 2013


  • Cancer prevention
  • Cancer syndromes
  • Driver mutations
  • Knudson
  • One-hit
  • Passenger mutations
  • Two-hit

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Developmental Biology

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