Heritable one-hit events defining cancer prevention?

Levy Kopelovich, Brittney-Shea Herbert

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Over 100 years ago (1902-1914) Theodor Boveri suggested a role for mutations in cancer.1,2 Boveri's ideas were derived from the then "just-emerging" chromosome theory of inheritance. While demonstrating chromosomal aberrations as a cause of genetic imbalance, Boveri suggested that possible causes of malignancy may include events such as aneuploidy that are now defined as gene mutations, asserting all the while that malignancy occurs at the cellular level. Indeed, studies to date essentially uniformly show that cancer is a genetic disease.

Original languageEnglish
Pages (from-to)2553-2557
Number of pages5
JournalCell Cycle
Volume12
Issue number16
DOIs
StatePublished - Aug 15 2013

Fingerprint

Neoplasms
Mutation
Inborn Genetic Diseases
Aneuploidy
Chromosome Aberrations
Chromosomes
Genes

Keywords

  • Cancer prevention
  • Cancer syndromes
  • Driver mutations
  • Knudson
  • One-hit
  • Passenger mutations
  • Two-hit

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Developmental Biology

Cite this

Heritable one-hit events defining cancer prevention? / Kopelovich, Levy; Herbert, Brittney-Shea.

In: Cell Cycle, Vol. 12, No. 16, 15.08.2013, p. 2553-2557.

Research output: Contribution to journalArticle

Kopelovich, Levy ; Herbert, Brittney-Shea. / Heritable one-hit events defining cancer prevention?. In: Cell Cycle. 2013 ; Vol. 12, No. 16. pp. 2553-2557.
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