Herpes simplex virus pneumonia. Clinical, virologic, and pathologic features in 20 patients

P. G. Ramsey, Kenneth Fife, R. C. Hackman, J. D. Meyers, L. Corey

Research output: Contribution to journalArticle

217 Citations (Scopus)

Abstract

Herpes simplex virus (herpesvirus) was isolated from autopsy lung specimens of 20 patients with clinical, roentgenographic, and histologic evidence of pneumonia. Mucocutaneous herpesvirus infection preceded the onset of pneumonia in 17. Twelve patients had focal pneumonia, 10 of whom had concomitant herpetic tracheitis, esophagitis, or both. Eight patients had diffuse interstitial pneumonia, six of whom had dissemination of herpesvirus to other organs. Of the eight lung isolates available for typing, seven were herpesvirus-1 and one, herpesvirus-2. A high prevalence of herpesvirus antibody in serum samples obtained before pneumonia and identical restriction endonuclease patterns between mucosal and lung isolates in individual patients indicated that, in most cases, herpesvirus pneumonia was due to endogenous reactivation of virus. Focal herpesvirus pneumonia appeared to result contiguous spread of herpesvirus to lung parenchyma, whereas diffuse interstitial pneumonia appeared to be a manifestation of hematogenous dissemination of virus.

Original languageEnglish (US)
Pages (from-to)813-820
Number of pages8
JournalAnnals of Internal Medicine
Volume97
Issue number6
StatePublished - 1982
Externally publishedYes

Fingerprint

Simplexvirus
Pneumonia
Lung
Interstitial Lung Diseases
Tracheitis
Viruses
Human Herpesvirus 2
Esophagitis
DNA Restriction Enzymes
Human Herpesvirus 1
Virus Diseases
Autopsy
Antibodies
Serum

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Ramsey, P. G., Fife, K., Hackman, R. C., Meyers, J. D., & Corey, L. (1982). Herpes simplex virus pneumonia. Clinical, virologic, and pathologic features in 20 patients. Annals of Internal Medicine, 97(6), 813-820.

Herpes simplex virus pneumonia. Clinical, virologic, and pathologic features in 20 patients. / Ramsey, P. G.; Fife, Kenneth; Hackman, R. C.; Meyers, J. D.; Corey, L.

In: Annals of Internal Medicine, Vol. 97, No. 6, 1982, p. 813-820.

Research output: Contribution to journalArticle

Ramsey, PG, Fife, K, Hackman, RC, Meyers, JD & Corey, L 1982, 'Herpes simplex virus pneumonia. Clinical, virologic, and pathologic features in 20 patients', Annals of Internal Medicine, vol. 97, no. 6, pp. 813-820.
Ramsey, P. G. ; Fife, Kenneth ; Hackman, R. C. ; Meyers, J. D. ; Corey, L. / Herpes simplex virus pneumonia. Clinical, virologic, and pathologic features in 20 patients. In: Annals of Internal Medicine. 1982 ; Vol. 97, No. 6. pp. 813-820.
@article{a3ddb084cc774451b27179fb1cd68b2c,
title = "Herpes simplex virus pneumonia. Clinical, virologic, and pathologic features in 20 patients",
abstract = "Herpes simplex virus (herpesvirus) was isolated from autopsy lung specimens of 20 patients with clinical, roentgenographic, and histologic evidence of pneumonia. Mucocutaneous herpesvirus infection preceded the onset of pneumonia in 17. Twelve patients had focal pneumonia, 10 of whom had concomitant herpetic tracheitis, esophagitis, or both. Eight patients had diffuse interstitial pneumonia, six of whom had dissemination of herpesvirus to other organs. Of the eight lung isolates available for typing, seven were herpesvirus-1 and one, herpesvirus-2. A high prevalence of herpesvirus antibody in serum samples obtained before pneumonia and identical restriction endonuclease patterns between mucosal and lung isolates in individual patients indicated that, in most cases, herpesvirus pneumonia was due to endogenous reactivation of virus. Focal herpesvirus pneumonia appeared to result contiguous spread of herpesvirus to lung parenchyma, whereas diffuse interstitial pneumonia appeared to be a manifestation of hematogenous dissemination of virus.",
author = "Ramsey, {P. G.} and Kenneth Fife and Hackman, {R. C.} and Meyers, {J. D.} and L. Corey",
year = "1982",
language = "English (US)",
volume = "97",
pages = "813--820",
journal = "Annals of Internal Medicine",
issn = "0003-4819",
publisher = "American College of Physicians",
number = "6",

}

TY - JOUR

T1 - Herpes simplex virus pneumonia. Clinical, virologic, and pathologic features in 20 patients

AU - Ramsey, P. G.

AU - Fife, Kenneth

AU - Hackman, R. C.

AU - Meyers, J. D.

AU - Corey, L.

PY - 1982

Y1 - 1982

N2 - Herpes simplex virus (herpesvirus) was isolated from autopsy lung specimens of 20 patients with clinical, roentgenographic, and histologic evidence of pneumonia. Mucocutaneous herpesvirus infection preceded the onset of pneumonia in 17. Twelve patients had focal pneumonia, 10 of whom had concomitant herpetic tracheitis, esophagitis, or both. Eight patients had diffuse interstitial pneumonia, six of whom had dissemination of herpesvirus to other organs. Of the eight lung isolates available for typing, seven were herpesvirus-1 and one, herpesvirus-2. A high prevalence of herpesvirus antibody in serum samples obtained before pneumonia and identical restriction endonuclease patterns between mucosal and lung isolates in individual patients indicated that, in most cases, herpesvirus pneumonia was due to endogenous reactivation of virus. Focal herpesvirus pneumonia appeared to result contiguous spread of herpesvirus to lung parenchyma, whereas diffuse interstitial pneumonia appeared to be a manifestation of hematogenous dissemination of virus.

AB - Herpes simplex virus (herpesvirus) was isolated from autopsy lung specimens of 20 patients with clinical, roentgenographic, and histologic evidence of pneumonia. Mucocutaneous herpesvirus infection preceded the onset of pneumonia in 17. Twelve patients had focal pneumonia, 10 of whom had concomitant herpetic tracheitis, esophagitis, or both. Eight patients had diffuse interstitial pneumonia, six of whom had dissemination of herpesvirus to other organs. Of the eight lung isolates available for typing, seven were herpesvirus-1 and one, herpesvirus-2. A high prevalence of herpesvirus antibody in serum samples obtained before pneumonia and identical restriction endonuclease patterns between mucosal and lung isolates in individual patients indicated that, in most cases, herpesvirus pneumonia was due to endogenous reactivation of virus. Focal herpesvirus pneumonia appeared to result contiguous spread of herpesvirus to lung parenchyma, whereas diffuse interstitial pneumonia appeared to be a manifestation of hematogenous dissemination of virus.

UR - http://www.scopus.com/inward/record.url?scp=0020371341&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020371341&partnerID=8YFLogxK

M3 - Article

C2 - 6293356

AN - SCOPUS:0020371341

VL - 97

SP - 813

EP - 820

JO - Annals of Internal Medicine

JF - Annals of Internal Medicine

SN - 0003-4819

IS - 6

ER -