Heterogeneity in Paget disease of the bone

Martha A. Nance, Frank Q. Nuttall, Michael J. Econs, Kenneth W. Lyles, Kristi D. Viles, Jeffery M. Vance, Margaret A. Pericak-Vance, Marcy C. Speer

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Paget disease of the bone is a common skeletal disorder. Recently, a gene for Paget disease was localized to 18q with subsequent evidence for linkage heterogeneity. We report the identification and clinical characterization of a large pedigree of Paget disease and demonstrate that the Paget disease gene in this pedigree is not linked to the region on 18q, thus confirming linkage heterogeneity. (C) 2000 Wiley-Liss, Inc.

Original languageEnglish (US)
Pages (from-to)303-307
Number of pages5
JournalAmerican journal of medical genetics
Volume92
Issue number5
DOIs
StatePublished - Jun 19 2000

Keywords

  • Heterogeneity
  • Paget disease

ASJC Scopus subject areas

  • Genetics(clinical)

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