High-Definition Colonoscopy Detects Colorectal Polyps at a Higher Rate Than Standard White-Light Colonoscopy

Anna M. Buchner, Muhammad W. Shahid, Michael G. Heckman, Rebecca B. McNeil, Patrick Cleveland, Kanwar R. Gill, Anthony Schore, Marwan Ghabril, Massimo Raimondo, Seth A. Gross, Michael B. Wallace

Research output: Contribution to journalArticle

85 Scopus citations


Background & Aims: Adenoma detection rates might be improved through use of high-definition colonoscopy, which can detect subtle mucosal changes. We investigated whether the use of high-definition white-light (HDWL) colonoscopy resulted in a higher rate of adenoma detection than standard-definition white-light (SDWL) colonoscopy in a clinical practice setting. Methods: This retrospective study included 2430 patients who underwent colonoscopies from September 2006 to December 2007; 1226 received SDWL colonoscopy and 1204 received HDWL colonoscopy. We analyzed data from consecutive screening, surveillance, and diagnostic colonoscopies, comparing adenoma and overall polyp detection between procedures. Potentially confounding variables were controlled using multivariable logistic regression analysis. Results: The adenoma detection rate was higher among patients who underwent HDWL compared with SDWL colonoscopies (28.8% vs 24.3%; P = .012), as was the polyp detection rate (42.2% vs 37.8%; P = .026). These findings remained after adjustments for potentially confounding variables (P = .018 and .022, respectively). Conclusions: In a general clinical practice setting, HDWL colonoscopy resulted in a higher adenoma detection rate compared with SDWL colonoscopy. The use of SDWL colonoscopy could reduce the number of missed adenomas and the subsequent risk for colorectal cancer.

Original languageEnglish (US)
Pages (from-to)364-370
Number of pages7
JournalClinical Gastroenterology and Hepatology
Issue number4
StatePublished - Apr 1 2010



  • Adenoma Detection
  • Colorectal Neoplasia

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

Cite this

Buchner, A. M., Shahid, M. W., Heckman, M. G., McNeil, R. B., Cleveland, P., Gill, K. R., Schore, A., Ghabril, M., Raimondo, M., Gross, S. A., & Wallace, M. B. (2010). High-Definition Colonoscopy Detects Colorectal Polyps at a Higher Rate Than Standard White-Light Colonoscopy. Clinical Gastroenterology and Hepatology, 8(4), 364-370. https://doi.org/10.1016/j.cgh.2009.11.009