High-density recording and topographic analysis of the auditory oddball event-related potential in patients with schizophrenia

Geoffrey F. Potts, Yoshio Hirayasu, Brian O'Donnell, Martha E. Shenton, Robert W. McCarley

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

Background: Prior research has shown reductions of the N1, N2, and P300 auditory event-related potential (ERP) components in schizophrenic patients. Most studies have shown a greater P300 reduction in left versus right temporal leads in schizophrenic patients. These studies were done with sparse electrode arrays, covering restricted areas of the head, thus providing an incomplete representation of the topographic field distribution. Methods: We used a 64-channel montage to acquire auditory oddball ERPs from 24 schizophrenic patients and 24 controls subjects. The N1, P2, N2, P300, and N2 difference (N2d) amplitudes and latencies were tested for group and laterality differences. Component topographies were mapped onto a three- dimensional head model to display the group differences. Results: The schizophrenic group showed reduction of the N1 component, perhaps reflecting reduced arousal or vigilance, but no N1 topographic difference. An N2d was not apparent in the schizophrenic patients, perhaps reflecting severe disruption in neural systems of stimulus categorization. In the patients, the P300 was smaller over the left temporal lobe sites than the right. Conclusions: The increased ERP spatial sampling allowed a more complete representation of the dipolar nature of the P300, which showed field contours consistent with neural sources in the posterior superior temporal plane.

Original languageEnglish (US)
Pages (from-to)982-989
Number of pages8
JournalBiological Psychiatry
Volume44
Issue number10
DOIs
StatePublished - Nov 15 1998
Externally publishedYes

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Evoked Potentials
Schizophrenia
Head
P300 Event-Related Potentials
Temporal Lobe
Arousal
Electrodes
Research

Keywords

  • 64-channel montage
  • Event-related potentials
  • N1
  • N2
  • P300
  • Schizophrenia

ASJC Scopus subject areas

  • Biological Psychiatry

Cite this

High-density recording and topographic analysis of the auditory oddball event-related potential in patients with schizophrenia. / Potts, Geoffrey F.; Hirayasu, Yoshio; O'Donnell, Brian; Shenton, Martha E.; McCarley, Robert W.

In: Biological Psychiatry, Vol. 44, No. 10, 15.11.1998, p. 982-989.

Research output: Contribution to journalArticle

Potts, Geoffrey F. ; Hirayasu, Yoshio ; O'Donnell, Brian ; Shenton, Martha E. ; McCarley, Robert W. / High-density recording and topographic analysis of the auditory oddball event-related potential in patients with schizophrenia. In: Biological Psychiatry. 1998 ; Vol. 44, No. 10. pp. 982-989.
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