High-Dose Chemotherapy and Autologous Stem Cell Transplant

Nabil Adra, Rafat Abonour

Research output: Contribution to journalReview article

Abstract

Germ cell tumors (GCT) are the most common cancer in men between 15 and 35 years of age and the incidence has increased during the past several decades. This article reviews the current knowledge on high-dose chemotherapy (HDCT) and stem cell transplant for salvage treatment of patients with relapsed metastatic GCT. Furthermore, the authors attempt to dissect the controversy of using standard-dose versus high-dose therapy as initial salvage and identify patients who are most likely to benefit from HDCT and peripheral blood stem cell transplant.

Original languageEnglish (US)
Pages (from-to)439-448
Number of pages10
JournalUrologic Clinics of North America
Volume46
Issue number3
DOIs
StatePublished - Aug 2019

Keywords

  • Germ cell tumor
  • High-dose chemotherapy
  • Salvage chemotherapy
  • Stem cell transplant
  • Testicular cancer

ASJC Scopus subject areas

  • Urology

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