High-dose chemotherapy in breast cancer -- the perils of history uncontrolled.

K. D. Miller, G. W. Sledge

Research output: Contribution to journalReview article

1 Scopus citations


Breast cancer remains a common and devastating disease that affects approximately 180,000 women and results in more than 43,000 deaths annually in the United States. Although only 10% of patients have overt metastatic disease at the time of diagnosis, as many as one third of those who present with lymph node-negative disease and half of those who present with lymph node-positive disease eventually develop metastatic breast cancer. With few exceptions, metastatic breast cancer is largely incurable, and the median duration of survival remains 18 to 24 months. Over the past 3 decades, both laboratory and clinical efforts to increase survival have focused on dose intensity in chemotherapy regimens.

Original languageEnglish (US)
Pages (from-to)E1
JournalMedscape women's health
Issue number3
StatePublished - 2000

ASJC Scopus subject areas

  • Medicine(all)

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