High-dose chemotherapy with autologous stem cell rescue for children with recurrent malignant brain tumors

Chie Schin Shih, Gregory A. Hale, Lindsey Gronewold, Xin Tong, Fred H. Laningham, Elizabeth A. Gilger, Deo Kumar Srivastava, Larry E. Kun, Amar Gajjar, Maryam Fouladi

Research output: Contribution to journalArticle

49 Scopus citations

Abstract

BACKGROUND. High-dose chemotherapy (HDCT) with autologous stem cell rescue (ASCR) has been reported to be effective in treating children with recurrent central nervous system (CNS) malignancies. METHODS. To evaluate the efficacy and toxicities of HDCT and ASCR, the medical records of 27 children with recurrent CNS malignancies who received such therapy at St. Jude Children's Research Hospital between 1989 and 2004 were reviewed. RESULTS. The median age at diagnosis was 4.5 years (range, 0.4-16.6 years) and that at ASCR was 6.7 years (range, 1.1-18.5 years). Diagnoses included medulloblastoma (13 patients), primitive neuroectodermal tumor (3 patients), pineoblastoma (2 patients), atypical teratoid rhabdoid tumor (2 patients), ependymoma (3 patients), anaplastic astrocytoma (2 patients), and glioblastoma multiforme (2 patients). The 5-year overall and progression-free survival (PFS) rates were 28.2% and 18.5%, respectively. The 5-year PFS rate for patients aged <3 years at diagnosis (57.1%) was significantly better than older patients (5.0%) (P = .019). Among the 6 long-term survivors (5 with M0 disease and 1 with M3 disease at diagnosis), 5 received both radiotherapy and HDCT as part of their salvage regimen; 4 were aged <3 years at diagnosis and had received chemotherapy only as part of frontline therapy. Two patients died of transplant-related toxicities; 44% experienced grade 3 or 4 transplant-related toxicities (toxicities were graded according to the National Cancer Institute Common Toxicity Criteria). CONCLUSIONS. HDCT with ASCR is not an effective salvage strategy for older children with recurrent CNS malignancies. The significantly better outcome in the younger cohort was most likely related to the use of radiotherapy as part of the salvage strategy.

Original languageEnglish (US)
Pages (from-to)1345-1353
Number of pages9
JournalCancer
Volume112
Issue number6
DOIs
StatePublished - Mar 15 2008
Externally publishedYes

Keywords

  • Autologous stem cell transplantation
  • Central nervous system neoplasms
  • High-dose chemotherapy
  • Recurrent
  • Salvage therapy

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'High-dose chemotherapy with autologous stem cell rescue for children with recurrent malignant brain tumors'. Together they form a unique fingerprint.

  • Cite this

    Shih, C. S., Hale, G. A., Gronewold, L., Tong, X., Laningham, F. H., Gilger, E. A., Srivastava, D. K., Kun, L. E., Gajjar, A., & Fouladi, M. (2008). High-dose chemotherapy with autologous stem cell rescue for children with recurrent malignant brain tumors. Cancer, 112(6), 1345-1353. https://doi.org/10.1002/cncr.23305