High grade prostatic intraepithelial neoplasia (HGPIN) and prostatic adenocarcinoma between the ages of 20-69

An autopsy study of 249 cases

W. A. Sakr, David Grignon, J. D. Crissman, L. K. Heilbrun, B. J. Cassin, J. J E Pontes, G. P. Haas

Research output: Contribution to journalArticle

429 Citations (Scopus)

Abstract

The relationship of prostatic intraepithelial neoplasia (PIN) and invasive carcinoma of the prostate is not fully understood. It is generally accepted that HGPIN is a probable preinvasive malignant change or at least a marker lesion for carcinoma. The prevalence of HGPIN in younger men is not known. Two hundred and forty nine entirely processed prostates from men aged 20-69 were thoroughly evaluated for the presence of PIN and carcinoma. The histologic diagnosis of all positive cases was confirmed by two pathologists. Our results are summarized as follows: Seventy seven percent of the prostates with HGPIN harbored adenocarcinoma, whereas the frequency of cancer in prostates without HGPIN was 24%. HGPIN was encountered in 0, 5, 10, 41 and 63% of men in the 3rd, 4th, 5th and 7th decades, respectively. The corresponding figures for invasive carcinoma were 2, 29, 32, 55, and 64% respectively.

Original languageEnglish (US)
Pages (from-to)439-444
Number of pages6
JournalIn Vivo
Volume8
Issue number3
StatePublished - 1994
Externally publishedYes

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Prostatic Intraepithelial Neoplasia
Autopsy
Adenocarcinoma
Prostate
Carcinoma
Carcinoma in Situ
Prostatic Neoplasms

Keywords

  • high grade prostatic intraepithelial neoplasia
  • latent vs clinical
  • prostatic adenocarcinoma

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Sakr, W. A., Grignon, D., Crissman, J. D., Heilbrun, L. K., Cassin, B. J., Pontes, J. J. E., & Haas, G. P. (1994). High grade prostatic intraepithelial neoplasia (HGPIN) and prostatic adenocarcinoma between the ages of 20-69: An autopsy study of 249 cases. In Vivo, 8(3), 439-444.

High grade prostatic intraepithelial neoplasia (HGPIN) and prostatic adenocarcinoma between the ages of 20-69 : An autopsy study of 249 cases. / Sakr, W. A.; Grignon, David; Crissman, J. D.; Heilbrun, L. K.; Cassin, B. J.; Pontes, J. J E; Haas, G. P.

In: In Vivo, Vol. 8, No. 3, 1994, p. 439-444.

Research output: Contribution to journalArticle

Sakr, WA, Grignon, D, Crissman, JD, Heilbrun, LK, Cassin, BJ, Pontes, JJE & Haas, GP 1994, 'High grade prostatic intraepithelial neoplasia (HGPIN) and prostatic adenocarcinoma between the ages of 20-69: An autopsy study of 249 cases', In Vivo, vol. 8, no. 3, pp. 439-444.
Sakr, W. A. ; Grignon, David ; Crissman, J. D. ; Heilbrun, L. K. ; Cassin, B. J. ; Pontes, J. J E ; Haas, G. P. / High grade prostatic intraepithelial neoplasia (HGPIN) and prostatic adenocarcinoma between the ages of 20-69 : An autopsy study of 249 cases. In: In Vivo. 1994 ; Vol. 8, No. 3. pp. 439-444.
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