High-Intensity Focused Ultrasound

M. Francesca Monn, Chandra K. Flack, Michael O. Koch

Research output: Chapter in Book/Report/Conference proceedingChapter


High-intensity focused ultrasound (HIFU) is a method of thermal ablation that is gaining popularity as an acceptable alternative to radical therapy in patients with localized prostate cancer (PCa). Through converging high-energy ultrasound waves, HIFU causes precise coagulative necrosis such that it avoids harm to outside structures and limits the morbidity (primarily urinary incontinence and erectile dysfunction) that occurs with radical prostatectomy and external-beam radiation therapy. Despite being originally pioneered as a method for primary whole-gland ablation in men who may otherwise not be candidates for radical therapy, it is now being tested as a means of focal therapy, particularly when combined with novel MR-imaging techniques, or as salvage therapy following surgical or radiation failure. Its primary advantage remains that it is a repeatable therapy, making it a versatile option either in isolation or as an adjunct to more traditional approaches.

Original languageEnglish (US)
Title of host publicationProstate Cancer
Subtitle of host publicationScience and Clinical Practice: Second Edition
PublisherElsevier Inc.
Number of pages12
ISBN (Print)9780128000779
StatePublished - Jan 1 2016


  • Focal therapy
  • High-intensity focused ultrasound (HIFU)
  • Prostate cancer
  • Thermal ablation

ASJC Scopus subject areas

  • Medicine(all)

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    Monn, M. F., Flack, C. K., & Koch, M. O. (2016). High-Intensity Focused Ultrasound. In Prostate Cancer: Science and Clinical Practice: Second Edition (pp. 551-562). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-800077-9.00059-1