High-intensity focused ultrasound (HIFU) multiple lesion imaging: Comparison of detection algorithms for real-time treatment control

Ralf Seip, Jahangir Tavakkoli, Roy F. Carlson, Adam Wunderlich, Narendra T. Sanghvi, Kris A. Dines, Thomas Gardner

Research output: Chapter in Book/Report/Conference proceedingConference contribution

16 Scopus citations

Abstract

Imaging of HIFU-induced lesions provides non-invasive, real-time treatment monitoring and control. This work presents results obtained with HIFU-induced lesion detection algorithms specifically designed for multiple lesion detection. Algorithms sensitive to relative tissue changes during HIFU - measuring signal energy, tissue displacement, entropy, and tissue attenuation are compared for their ability to detect the creation of multiple and adjacent HIFU lesions. In vivo (N=4) canine prostate backscattered RF data was acquired with a custom Sonablate® 500 HIFU device during 7 treatments. A total of 815 sites were treated, forming the algorithm evaluation dataset. It was found that the algorithm based on signal energy performed best, detecting 82% of all HIFU lesions created, while showing false-alarm rates below 5%. All methods are completely non-invasive, and make use of tissue reference/normalization information obtained before, during, and after the HIFU treatment. Algorithm specifics, data acquisition methodologies, in vivo experimental results, and algorithm comparison results are shown.

Original languageEnglish
Title of host publicationProceedings of the IEEE Ultrasonics Symposium
EditorsD.E. Yuhas, S.C. Schneider
Pages1427-1430
Number of pages4
Volume2
StatePublished - 2002
Event2002 IEEE Ultrasonics Symposium - Munich, Germany
Duration: Oct 8 2002Oct 11 2002

Other

Other2002 IEEE Ultrasonics Symposium
CountryGermany
CityMunich
Period10/8/0210/11/02

ASJC Scopus subject areas

  • Engineering(all)

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    Seip, R., Tavakkoli, J., Carlson, R. F., Wunderlich, A., Sanghvi, N. T., Dines, K. A., & Gardner, T. (2002). High-intensity focused ultrasound (HIFU) multiple lesion imaging: Comparison of detection algorithms for real-time treatment control. In D. E. Yuhas, & S. C. Schneider (Eds.), Proceedings of the IEEE Ultrasonics Symposium (Vol. 2, pp. 1427-1430)