High levels of Alzheimer beta-amyloid precursor protein (APP) in children with severely autistic behavior and aggression

Deborah Sokol, Demao Chen, Martin Farlow, David Dunn, Bryan Maloney, Jennifer A. Zimmer, Debomoy Lahiri

Research output: Contribution to journalArticle

74 Citations (Scopus)

Abstract

Autism is characterized by restricted, repetitive behaviors and impairment in socialization and communication. Although no neuropathologic substrate underlying autism has been found, the findings of brain overgrowth via neuroimaging studies and increased levels of brain-derived neurotrophic factor (BDNF) in neuropathologic and blood studies favor an anabolic state. We examined acetylcholinesterase, plasma neuronal proteins, secreted beta-amyloid precursor protein (APP), and amyloid-beta 40 and amyloid-beta 42 peptides in children with and without autism. Children with severe autism and aggression expressed secreted beta-amyloid precursor protein at two or more times the levels of children without autism and up to four times more than children with mild autism. There was a trend for children with autism to show higher levels of secreted beta-amyloid precursor protein and nonamyloidogenic secreted beta-amyloid precursor protein and lower levels of amyloid-beta 40 compared with controls. This favors an increased α-secretase pathway in autism (anabolic), opposite to what is seen in Alzheimer disease. Additionally, a complex relationship between age, acetylcholinesterase, and plasma neuronal markers was found.

Original languageEnglish
Pages (from-to)444-449
Number of pages6
JournalJournal of Child Neurology
Volume21
Issue number6
DOIs
StatePublished - Jun 2006

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Amyloid beta-Protein Precursor
Autistic Disorder
Aggression
Acetylcholinesterase
Amyloid
Amyloid Precursor Protein Secretases
Socialization
Brain-Derived Neurotrophic Factor
Neuroimaging
Blood Proteins
Alzheimer Disease
Communication
Brain

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health

Cite this

High levels of Alzheimer beta-amyloid precursor protein (APP) in children with severely autistic behavior and aggression. / Sokol, Deborah; Chen, Demao; Farlow, Martin; Dunn, David; Maloney, Bryan; Zimmer, Jennifer A.; Lahiri, Debomoy.

In: Journal of Child Neurology, Vol. 21, No. 6, 06.2006, p. 444-449.

Research output: Contribution to journalArticle

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