High rate of microbleed formation following primary intracerebral hemorrhage

Jason Mackey, Jeffrey J. Wing, Gina Norato, Ian Sobotka, Ravi S. Menon, Richard E. Burgess, M. Chris Gibbons, Nawar M. Shara, Stephen Fernandez, Annapurni Jayam-Trouth, Laura Russell, Dorothy F. Edwards, Chelsea S. Kidwell

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: We sought to investigate the frequency of microbleed development following intracerebral hemorrhage in a predominantly African-American population and to identify predictors of new microbleed formation.Aims and/or hypothesis: To investigate the frequency and predictors of new microbleeds following intracerebral hemorrhage.Methods: The DECIPHER study was a prospective, longitudinal, magnetic resonance-based cohort study designed to evaluate racial/ethnic differences in risk factors for microbleeds and to evaluate the prognostic impact of microbleeds in this intracerebral hemorrhage population. We evaluated new microbleed formation in two time periods: from baseline to 30 days and from 30 days to year 1.Results: Of 200 subjects enrolled in DECIPHER, 84 had magnetic resonance imaging at all required time points to meet criteria for this analysis. In the baseline to day 30 analysis, 11 (13·1%) had new microbleeds, compared with 25 (29·8%) in the day 30 to year 1 analysis. Logistic regression analysis demonstrated that baseline number of microbleeds [odds ratio 1·05 (95% confidence interval 1·01, 1·08), P = 0·01] was associated with new microbleed formation at 30 days. A logistic regression model predicting new microbleed at one-year included baseline number of microbleeds [odds ratio 1·05 (1·00, 1·11), P = 0·046], baseline age [odds ratio 1·05 (1·00, 1·10), P = 0·04], and white matter disease score [odds ratio 1·18 (0·96, 1·45). P = 0·115]. Overall, 28 of 84 (33·3%) intracerebral hemorrhage subjects formed new microbleeds at some point in the first year post-intracerebral hemorrhage.Conclusions: We found that one-third of intracerebral hemorrhage subjects in this cohort surviving one-year developed new microbleeds, which suggests a dynamic and rapidly progressive vasculopathy. Future studies are needed to examine the impact of new microbleed formation on patient outcomes.

Original languageEnglish (US)
Pages (from-to)1187-1191
Number of pages5
JournalInternational Journal of Stroke
Volume10
Issue number8
DOIs
StatePublished - Dec 1 2015

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Cerebral Hemorrhage
Odds Ratio
Logistic Models
Leukoencephalopathies
African Americans
Population
Cohort Studies
Magnetic Resonance Spectroscopy
Regression Analysis
Magnetic Resonance Imaging
Confidence Intervals

Keywords

  • Brain bleed
  • brain microbleeds
  • cerebral hemorrhage
  • hemorrhage
  • intracerebral hemorrhage
  • MRI

ASJC Scopus subject areas

  • Neurology

Cite this

Mackey, J., Wing, J. J., Norato, G., Sobotka, I., Menon, R. S., Burgess, R. E., ... Kidwell, C. S. (2015). High rate of microbleed formation following primary intracerebral hemorrhage. International Journal of Stroke, 10(8), 1187-1191. https://doi.org/10.1111/ijs.12607

High rate of microbleed formation following primary intracerebral hemorrhage. / Mackey, Jason; Wing, Jeffrey J.; Norato, Gina; Sobotka, Ian; Menon, Ravi S.; Burgess, Richard E.; Gibbons, M. Chris; Shara, Nawar M.; Fernandez, Stephen; Jayam-Trouth, Annapurni; Russell, Laura; Edwards, Dorothy F.; Kidwell, Chelsea S.

In: International Journal of Stroke, Vol. 10, No. 8, 01.12.2015, p. 1187-1191.

Research output: Contribution to journalArticle

Mackey, J, Wing, JJ, Norato, G, Sobotka, I, Menon, RS, Burgess, RE, Gibbons, MC, Shara, NM, Fernandez, S, Jayam-Trouth, A, Russell, L, Edwards, DF & Kidwell, CS 2015, 'High rate of microbleed formation following primary intracerebral hemorrhage', International Journal of Stroke, vol. 10, no. 8, pp. 1187-1191. https://doi.org/10.1111/ijs.12607
Mackey, Jason ; Wing, Jeffrey J. ; Norato, Gina ; Sobotka, Ian ; Menon, Ravi S. ; Burgess, Richard E. ; Gibbons, M. Chris ; Shara, Nawar M. ; Fernandez, Stephen ; Jayam-Trouth, Annapurni ; Russell, Laura ; Edwards, Dorothy F. ; Kidwell, Chelsea S. / High rate of microbleed formation following primary intracerebral hemorrhage. In: International Journal of Stroke. 2015 ; Vol. 10, No. 8. pp. 1187-1191.
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abstract = "Background: We sought to investigate the frequency of microbleed development following intracerebral hemorrhage in a predominantly African-American population and to identify predictors of new microbleed formation.Aims and/or hypothesis: To investigate the frequency and predictors of new microbleeds following intracerebral hemorrhage.Methods: The DECIPHER study was a prospective, longitudinal, magnetic resonance-based cohort study designed to evaluate racial/ethnic differences in risk factors for microbleeds and to evaluate the prognostic impact of microbleeds in this intracerebral hemorrhage population. We evaluated new microbleed formation in two time periods: from baseline to 30 days and from 30 days to year 1.Results: Of 200 subjects enrolled in DECIPHER, 84 had magnetic resonance imaging at all required time points to meet criteria for this analysis. In the baseline to day 30 analysis, 11 (13·1{\%}) had new microbleeds, compared with 25 (29·8{\%}) in the day 30 to year 1 analysis. Logistic regression analysis demonstrated that baseline number of microbleeds [odds ratio 1·05 (95{\%} confidence interval 1·01, 1·08), P = 0·01] was associated with new microbleed formation at 30 days. A logistic regression model predicting new microbleed at one-year included baseline number of microbleeds [odds ratio 1·05 (1·00, 1·11), P = 0·046], baseline age [odds ratio 1·05 (1·00, 1·10), P = 0·04], and white matter disease score [odds ratio 1·18 (0·96, 1·45). P = 0·115]. Overall, 28 of 84 (33·3{\%}) intracerebral hemorrhage subjects formed new microbleeds at some point in the first year post-intracerebral hemorrhage.Conclusions: We found that one-third of intracerebral hemorrhage subjects in this cohort surviving one-year developed new microbleeds, which suggests a dynamic and rapidly progressive vasculopathy. Future studies are needed to examine the impact of new microbleed formation on patient outcomes.",
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AU - Wing, Jeffrey J.

AU - Norato, Gina

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AU - Burgess, Richard E.

AU - Gibbons, M. Chris

AU - Shara, Nawar M.

AU - Fernandez, Stephen

AU - Jayam-Trouth, Annapurni

AU - Russell, Laura

AU - Edwards, Dorothy F.

AU - Kidwell, Chelsea S.

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