High-speed intravascular photoacoustic imaging of lipid-laden atherosclerotic plaque enabled by a 2-kHz Barium Nitrite Raman Laser

Pu Wang, Teng Ma, Mikhail N. Slipchenko, Shanshan Liang, Jie Hui, K. Kirk Shung, Sukesh Roy, Michael Sturek, Qifa Zhou, Zhongping Chen, Ji Xin Cheng

Research output: Contribution to journalArticle

85 Scopus citations

Abstract

Lipid deposition inside the arterial wall is a key indicator of plaque vulnerability. An intravascular photoacoustic (IVPA) catheter is considered a promising device for quantifying the amount of lipid inside the arterial wall. Thus far, IVPA systems suffered from slow imaging speed (∼50 s per frame) due to the lack of a suitable laser source for high-speed excitation of molecular overtone vibrations. Here, we report an improvement in IVPA imaging speed by two orders of magnitude, to 1.0 s per frame, enabled by a custom-built, 2-kHz master oscillator power amplifier (MOPA)-pumped, barium nitrite [Ba(NO3)2] Raman laser. This advancement narrows the gap in translating the IVPA technology to the clinical setting.

Original languageEnglish (US)
Article number6889
JournalScientific reports
Volume4
DOIs
StatePublished - Nov 4 2014

ASJC Scopus subject areas

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    Wang, P., Ma, T., Slipchenko, M. N., Liang, S., Hui, J., Shung, K. K., Roy, S., Sturek, M., Zhou, Q., Chen, Z., & Cheng, J. X. (2014). High-speed intravascular photoacoustic imaging of lipid-laden atherosclerotic plaque enabled by a 2-kHz Barium Nitrite Raman Laser. Scientific reports, 4, [6889]. https://doi.org/10.1038/srep06889