Higher dietary lycopene intake is associated with longer cardiac event-free survival in patients with heart failure

Martha Biddle, Debra Moser, Eun Kyeung Song, Seongkum Heo, Heather Payne-Emerson, Sandra B. Dunbar, Susan Pressler, Terry Lennie

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background: The antioxidant lycopene may be beneficial for patients with heart failure (HF). Processed tomato products are a major source of lycopene, although they are also high in sodium. Increased sodium intake may counter the positive antioxidant effect of lycopene. Methods: This was a prospective study of 212 patients with HF. Dietary intake of lycopene and sodium was obtained from weighted 4-day food diaries. Patients were grouped by the median split of lycopene of 2471 μg/day and stratified by daily sodium levels above and below 3 g/day. Patients were followed for 1 year to collect survival and hospitalization data. Cox proportional hazards modeling was used to compare cardiac event-free survival between lycopene groups within each stratum of sodium intake. Results: Higher lycopene intake was associated with longer cardiac event-free survival compared with lower lycopene intake (p = 0.003). The worst cardiac event-free survival was observed in the low lycopene intake group regardless of sodium intake (> 3 g/day HR = 3.01; p = 0.027 and ≤ 3 g/day HR= 3.34; p = 0.023). Conclusion: These findings suggest that increased lycopene intake has the potential to improve cardiac event-free survival in patients with HF independent of sodium intake.

Original languageEnglish (US)
Pages (from-to)377-384
Number of pages8
JournalEuropean Journal of Cardiovascular Nursing
Volume12
Issue number4
DOIs
StatePublished - Aug 2013
Externally publishedYes

Fingerprint

Disease-Free Survival
Heart Failure
Sodium
Antioxidants
lycopene
Diet Records
Lycopersicon esculentum
Hospitalization
Prospective Studies
Survival

Keywords

  • antioxidants
  • heart failure
  • Lycopene
  • sodium

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialized Nursing
  • Medical–Surgical

Cite this

Higher dietary lycopene intake is associated with longer cardiac event-free survival in patients with heart failure. / Biddle, Martha; Moser, Debra; Song, Eun Kyeung; Heo, Seongkum; Payne-Emerson, Heather; Dunbar, Sandra B.; Pressler, Susan; Lennie, Terry.

In: European Journal of Cardiovascular Nursing, Vol. 12, No. 4, 08.2013, p. 377-384.

Research output: Contribution to journalArticle

Biddle, Martha ; Moser, Debra ; Song, Eun Kyeung ; Heo, Seongkum ; Payne-Emerson, Heather ; Dunbar, Sandra B. ; Pressler, Susan ; Lennie, Terry. / Higher dietary lycopene intake is associated with longer cardiac event-free survival in patients with heart failure. In: European Journal of Cardiovascular Nursing. 2013 ; Vol. 12, No. 4. pp. 377-384.
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