Highly variable gastric emptying in patients with insulin dependent diabetes mellitus

Thomas Nowak, C. P. Johnson, J. H. Kalbfleisch, A. M. Roza, C. M. Wood, J. P. Weisbruch, K. H. Soergel

Research output: Contribution to journalArticle

101 Citations (Scopus)

Abstract

Some diabetic patients - particularly those with nausea and vomiting - frequently have evidence of delayed gastric emptying while other diabetic patients may in fact exhibit accelerated gastric emptying. Whether the presence or absence of symptoms of upper gastrointestinal dysfunction correlated with objective measures of gastric emptying in insulin dependent diabetic subjects was investigated. Twenty one insulin dependent diabetic patients underwent a solid phase gastric emptying scintiscan using in vivo labelled chicken patients had symptoms Thirteen patients had symptoms suggestive of gastrointestinal dysfunction (nausea, vomiting, early satiety, or constipation), while eight patients had no gastrointestinal symptoms. Eleven patients had orthostatic hypotension. All patients had been diabetic since childhood or adolescence. As a group, the diabetic patients showed a half time (T50) of gastric emptying (mean (SD) 150.0 min (163.7) that was not significantly different from that of 12 healthy control subjects (148.1 min (62.4)). Those diabetic patients without gastrointestinal symptoms and without orthostatic hypotension, however, showed a gastric emptying half time (70.1 min (41.6)) that was significantly faster than that of the control subjects. Conversely, those diabetic patients with nausea, vomiting, and early satiety (or early satiety alone) showed T50 values that were significantly greater than those of the diabetic patients without these symptoms. No correlation was found between the T50 value and the duration of diabetes, the fasting blood glucose at the time of study, or the respiratory variation in heart rate (E:I ratio). These observations indicate that highly variable rates of gastric emptying occur in insulin dependent diabetic patients, and that accelerated gastric emptying may occur in diabetic patients who have no symptoms of gastrointestinal dysfunction.

Original languageEnglish (US)
Pages (from-to)23-29
Number of pages7
JournalGut
Volume37
Issue number1
StatePublished - 1995

Fingerprint

Gastric Emptying
Type 1 Diabetes Mellitus
Nausea
Vomiting
Orthostatic Hypotension
Insulin
Time and Motion Studies
Constipation
Blood Glucose
Chickens
Fasting
Healthy Volunteers

Keywords

  • Autonomic neuropathy
  • Gastric emptying

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Nowak, T., Johnson, C. P., Kalbfleisch, J. H., Roza, A. M., Wood, C. M., Weisbruch, J. P., & Soergel, K. H. (1995). Highly variable gastric emptying in patients with insulin dependent diabetes mellitus. Gut, 37(1), 23-29.

Highly variable gastric emptying in patients with insulin dependent diabetes mellitus. / Nowak, Thomas; Johnson, C. P.; Kalbfleisch, J. H.; Roza, A. M.; Wood, C. M.; Weisbruch, J. P.; Soergel, K. H.

In: Gut, Vol. 37, No. 1, 1995, p. 23-29.

Research output: Contribution to journalArticle

Nowak, T, Johnson, CP, Kalbfleisch, JH, Roza, AM, Wood, CM, Weisbruch, JP & Soergel, KH 1995, 'Highly variable gastric emptying in patients with insulin dependent diabetes mellitus', Gut, vol. 37, no. 1, pp. 23-29.
Nowak T, Johnson CP, Kalbfleisch JH, Roza AM, Wood CM, Weisbruch JP et al. Highly variable gastric emptying in patients with insulin dependent diabetes mellitus. Gut. 1995;37(1):23-29.
Nowak, Thomas ; Johnson, C. P. ; Kalbfleisch, J. H. ; Roza, A. M. ; Wood, C. M. ; Weisbruch, J. P. ; Soergel, K. H. / Highly variable gastric emptying in patients with insulin dependent diabetes mellitus. In: Gut. 1995 ; Vol. 37, No. 1. pp. 23-29.
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