HIPDM-SPECT brain imaging in the presurgical evaluation of patients with intractable seizures

W. Shen, B. I. Lee, H. M. Park, A. R. Siddiqui, H. H. Wellman, R. M. Worth, Omkar Markand

Research output: Contribution to journalArticle

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Abstract

We report the results of interictal and ictal HIPDM-SPECT brain imaging in 34 patients who eventually underwent temporal lobectomy for treatment of medically intractable complex partial seizures. Interictal studies revealed decreased regional cerebral perfusion (rCP) in the temporal lobe corresponding to the eventual site of surgery in 73% of the patients. Similarly, ictal study demonstrated increased rCP in 93% of the patients. In 69% of the patients, the SPECT studies were able to demonstrate both increased rCP on the ictal scan and decreased rCP on the interictal scan in the same location, corresponding to the eventual site of surgery. These results suggest that interictal and ictal SPECT brain imaging can be easily obtained and provide reliable localizing information in the presurgical evaluation of patients with medically intractable epilepsy.

Original languageEnglish
Pages (from-to)1280-1284
Number of pages5
JournalJournal of Nuclear Medicine
Volume31
Issue number8
StatePublished - 1990

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Single-Photon Emission-Computed Tomography
Neuroimaging
Seizures
Perfusion
Stroke
Temporal Lobe
N,N,N'-trimethyl-N'-(2-hydroxy-3-methyl-5-iodobenzyl)-1,3-propanediamine
Therapeutics

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Shen, W., Lee, B. I., Park, H. M., Siddiqui, A. R., Wellman, H. H., Worth, R. M., & Markand, O. (1990). HIPDM-SPECT brain imaging in the presurgical evaluation of patients with intractable seizures. Journal of Nuclear Medicine, 31(8), 1280-1284.

HIPDM-SPECT brain imaging in the presurgical evaluation of patients with intractable seizures. / Shen, W.; Lee, B. I.; Park, H. M.; Siddiqui, A. R.; Wellman, H. H.; Worth, R. M.; Markand, Omkar.

In: Journal of Nuclear Medicine, Vol. 31, No. 8, 1990, p. 1280-1284.

Research output: Contribution to journalArticle

Shen, W, Lee, BI, Park, HM, Siddiqui, AR, Wellman, HH, Worth, RM & Markand, O 1990, 'HIPDM-SPECT brain imaging in the presurgical evaluation of patients with intractable seizures', Journal of Nuclear Medicine, vol. 31, no. 8, pp. 1280-1284.
Shen W, Lee BI, Park HM, Siddiqui AR, Wellman HH, Worth RM et al. HIPDM-SPECT brain imaging in the presurgical evaluation of patients with intractable seizures. Journal of Nuclear Medicine. 1990;31(8):1280-1284.
Shen, W. ; Lee, B. I. ; Park, H. M. ; Siddiqui, A. R. ; Wellman, H. H. ; Worth, R. M. ; Markand, Omkar. / HIPDM-SPECT brain imaging in the presurgical evaluation of patients with intractable seizures. In: Journal of Nuclear Medicine. 1990 ; Vol. 31, No. 8. pp. 1280-1284.
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