Hippocampal shape analysis: Surface-based representation and classification

Li Shen, James Ford, Fillia Makedon, Andrew Saykin

Research output: Contribution to journalConference article

34 Scopus citations


Surface-based representation and classification techniques are studied for hippocampal shape analysis. The goal is twofold: (1) develop a new framework of salient feature extraction and accurate classification for 3D shape data: (2) detect hippocampal abnormalities in schizophrenia using this technique. A fine-scale spherical harmonic expansion is employed to describe a closed 3D surface object. The expansion can then easily be transformed to extract only shape information (i.e., excluding translation, rotation, and scaling) and create a shape descriptor comparable across different individuals. This representation captures shape features and is flexible enough to do shape modeling, identify statistical group differences, and generate similar synthetic shapes. Principal component analysis is used to extract a small number of independent features from high dimensional shape descriptors, and Fisher's linear discriminant is applied for pattern classification. This framework is shown to be able to perform well in distinguishing clear group differences as well as small and noisy group differences using simulated shape data. In addition, the application of this technique to real data indicates that group shape differences exist in hippocampi between healthy controls and schizophrenic patients.

Original languageEnglish (US)
Pages (from-to)253-264
Number of pages12
JournalProceedings of SPIE - The International Society for Optical Engineering
Volume5032 I
StatePublished - Sep 15 2003
Externally publishedYes
EventMedical Imaging 2003: Image Processing - San Diego, CA, United States
Duration: Feb 17 2003Feb 20 2003


  • Classification
  • Hippocampus
  • MRI
  • Shape analysis
  • Surface modeling

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

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