Histamine tachyphylaxis in canine airways despite prostaglandin synthesis inhibition

P. J. Antol, Susan Gunst, R. E. Hyatt

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Tachyphylaxis to aerosolized histamine was studied in dogs anesthetized with thiamylal after pretreatment with prostaglandin synthesis inhibitors. Three consecutive histamine dose-response curves were obtained in nine dogs pretreated with 5 mg/kg indomethacin; two of these nine were also pretreated with 10 mg/kg indomethacin. Seven of the nine dogs were pretreated with 4 mg/kg sodium meclofenamate; four of these seven were also pretreated with 12 mg/kg. All dogs had tachyphylaxis at high concentrations of histamine regardless of inhibitor used. Pretreatment with indomethacin while the dogs were under α-chloralose-urethan anesthesia gave similar results. Histamine tachyphylaxis was also studied both in the presence and in the absence of indomethacin in tracheal smooth muscle strips obtained from seven additional dogs. A decrease in the median effective dose to histamine was observed in the indomethacin-treated strips, but tachyphylaxis to histamine remained. We conclude that prostaglandin synthesis inhibition does not reverse histamine tachyphylaxis either in vivo or in vitro. Thus the mechanism of histamine tachyphylaxis remains unexplained.

Original languageEnglish (US)
Pages (from-to)1944-1949
Number of pages6
JournalJournal of Applied Physiology
Volume65
Issue number5
StatePublished - 1988
Externally publishedYes

Fingerprint

Tachyphylaxis
Histamine
Prostaglandins
Canidae
Indomethacin
Dogs
Thiamylal
Meclofenamic Acid
Prostaglandin Antagonists
Chloralose
Urethane
Smooth Muscle
Anesthesia

ASJC Scopus subject areas

  • Endocrinology
  • Physiology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Histamine tachyphylaxis in canine airways despite prostaglandin synthesis inhibition. / Antol, P. J.; Gunst, Susan; Hyatt, R. E.

In: Journal of Applied Physiology, Vol. 65, No. 5, 1988, p. 1944-1949.

Research output: Contribution to journalArticle

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