Histologic confirmation of neuronal cell bodies along the spinal accessory nerve

R. Shane Tubbs, Edward P. Sorenson, Koichi Watanabe, Marios Loukas, Eyas Hattab, Aaron Cohen-Gadol

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Introduction. Most sources conclude that the spinal accessory nerve (SAN) is a purely motor nerve. There are some reports that suggest a sensory component, although the exact nature of such sensory fibers has yet to be elucidated. With such discrepancies in the literature and with well-established pain syndromes of unknown etiology following SAN injury, the authors performed the present study to better clarify this anatomy. Materials and methods. The entire accessory nerve was harvested from 10 adult cadavers. Samples were then submitted for immunohistochemical analyses. Results. Occasional microganglia cells were identified along the SAN in all specimens. These ganglia were most numerous along the intracranial segment of the SAN, but none was found along the cranial rootlets of the accessory nerve. Conclusions. Neuronal cell bodies were identified along the course of the SAN in human cadavers. Although the function is not certain, such cells have been found in other animals to be nocioceptive in nature. Pending further study, these cells may be found to be involved in enigmatic pain syndromes thought to arise in the sternocleidomastoid and trapezius muscles.

Original languageEnglish
Pages (from-to)746-749
Number of pages4
JournalBritish Journal of Neurosurgery
Volume28
Issue number6
DOIs
StatePublished - Dec 1 2014

Fingerprint

Accessory Nerve
Cadaver
Accessory Nerve Injuries
Pain
Superficial Back Muscles
Ganglia
Cell Body
Anatomy

Keywords

  • Accessory nerve
  • Anatomy
  • Cranial nerve XI
  • Neck
  • Neurosurgery
  • Pain syndromes

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery
  • Medicine(all)

Cite this

Histologic confirmation of neuronal cell bodies along the spinal accessory nerve. / Tubbs, R. Shane; Sorenson, Edward P.; Watanabe, Koichi; Loukas, Marios; Hattab, Eyas; Cohen-Gadol, Aaron.

In: British Journal of Neurosurgery, Vol. 28, No. 6, 01.12.2014, p. 746-749.

Research output: Contribution to journalArticle

Tubbs, R. Shane ; Sorenson, Edward P. ; Watanabe, Koichi ; Loukas, Marios ; Hattab, Eyas ; Cohen-Gadol, Aaron. / Histologic confirmation of neuronal cell bodies along the spinal accessory nerve. In: British Journal of Neurosurgery. 2014 ; Vol. 28, No. 6. pp. 746-749.
@article{453ecaa2742e436d8d255618f2795df0,
title = "Histologic confirmation of neuronal cell bodies along the spinal accessory nerve",
abstract = "Introduction. Most sources conclude that the spinal accessory nerve (SAN) is a purely motor nerve. There are some reports that suggest a sensory component, although the exact nature of such sensory fibers has yet to be elucidated. With such discrepancies in the literature and with well-established pain syndromes of unknown etiology following SAN injury, the authors performed the present study to better clarify this anatomy. Materials and methods. The entire accessory nerve was harvested from 10 adult cadavers. Samples were then submitted for immunohistochemical analyses. Results. Occasional microganglia cells were identified along the SAN in all specimens. These ganglia were most numerous along the intracranial segment of the SAN, but none was found along the cranial rootlets of the accessory nerve. Conclusions. Neuronal cell bodies were identified along the course of the SAN in human cadavers. Although the function is not certain, such cells have been found in other animals to be nocioceptive in nature. Pending further study, these cells may be found to be involved in enigmatic pain syndromes thought to arise in the sternocleidomastoid and trapezius muscles.",
keywords = "Accessory nerve, Anatomy, Cranial nerve XI, Neck, Neurosurgery, Pain syndromes",
author = "Tubbs, {R. Shane} and Sorenson, {Edward P.} and Koichi Watanabe and Marios Loukas and Eyas Hattab and Aaron Cohen-Gadol",
year = "2014",
month = "12",
day = "1",
doi = "10.3109/02688697.2014.920485",
language = "English",
volume = "28",
pages = "746--749",
journal = "British Journal of Neurosurgery",
issn = "0268-8697",
publisher = "Informa Healthcare",
number = "6",

}

TY - JOUR

T1 - Histologic confirmation of neuronal cell bodies along the spinal accessory nerve

AU - Tubbs, R. Shane

AU - Sorenson, Edward P.

AU - Watanabe, Koichi

AU - Loukas, Marios

AU - Hattab, Eyas

AU - Cohen-Gadol, Aaron

PY - 2014/12/1

Y1 - 2014/12/1

N2 - Introduction. Most sources conclude that the spinal accessory nerve (SAN) is a purely motor nerve. There are some reports that suggest a sensory component, although the exact nature of such sensory fibers has yet to be elucidated. With such discrepancies in the literature and with well-established pain syndromes of unknown etiology following SAN injury, the authors performed the present study to better clarify this anatomy. Materials and methods. The entire accessory nerve was harvested from 10 adult cadavers. Samples were then submitted for immunohistochemical analyses. Results. Occasional microganglia cells were identified along the SAN in all specimens. These ganglia were most numerous along the intracranial segment of the SAN, but none was found along the cranial rootlets of the accessory nerve. Conclusions. Neuronal cell bodies were identified along the course of the SAN in human cadavers. Although the function is not certain, such cells have been found in other animals to be nocioceptive in nature. Pending further study, these cells may be found to be involved in enigmatic pain syndromes thought to arise in the sternocleidomastoid and trapezius muscles.

AB - Introduction. Most sources conclude that the spinal accessory nerve (SAN) is a purely motor nerve. There are some reports that suggest a sensory component, although the exact nature of such sensory fibers has yet to be elucidated. With such discrepancies in the literature and with well-established pain syndromes of unknown etiology following SAN injury, the authors performed the present study to better clarify this anatomy. Materials and methods. The entire accessory nerve was harvested from 10 adult cadavers. Samples were then submitted for immunohistochemical analyses. Results. Occasional microganglia cells were identified along the SAN in all specimens. These ganglia were most numerous along the intracranial segment of the SAN, but none was found along the cranial rootlets of the accessory nerve. Conclusions. Neuronal cell bodies were identified along the course of the SAN in human cadavers. Although the function is not certain, such cells have been found in other animals to be nocioceptive in nature. Pending further study, these cells may be found to be involved in enigmatic pain syndromes thought to arise in the sternocleidomastoid and trapezius muscles.

KW - Accessory nerve

KW - Anatomy

KW - Cranial nerve XI

KW - Neck

KW - Neurosurgery

KW - Pain syndromes

UR - http://www.scopus.com/inward/record.url?scp=84911128129&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84911128129&partnerID=8YFLogxK

U2 - 10.3109/02688697.2014.920485

DO - 10.3109/02688697.2014.920485

M3 - Article

C2 - 24902994

AN - SCOPUS:84911128129

VL - 28

SP - 746

EP - 749

JO - British Journal of Neurosurgery

JF - British Journal of Neurosurgery

SN - 0268-8697

IS - 6

ER -