Histological and ultrastructural evaluation of cardiac lesions in idiopathic cardiomyopathy in dogs

George Sandusky, C. C. Capen, K. M. Kerr

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Described are pathological studies of eight dogs which died in congestive heart failure, with a clinical diagnosis of congestive cardiomyopathy. Examination revealed marked dilatation and enlargement of all four chambers of the heart. The ventricular walls were thin with small atrophic papillary muscles. Histological studies on the myocardium revealed scattered areas of myocardial necrosis, especially around the papillary muscles of the left ventricle and random scattered areas of fibrosis. Electron microscopic studies revealed fewer and disoriented myofibrils, myocytolysis, increased numbers of mitochondria with swelling and inclusions, increased glycogen granules and increased numbers of lysosomes, lipofuscin granules and lipid droplets. Mild Z-band abnormalities were found throughout the myofibers.

Original languageEnglish (US)
Pages (from-to)81-86
Number of pages6
JournalCanadian Journal of Comparative Medicine
Volume48
Issue number1
StatePublished - 1984
Externally publishedYes

Fingerprint

Papillary Muscles
cardiomyopathy
Cardiomyopathies
lesions (animal)
granules
Dogs
Lipofuscin
muscles
Myofibrils
dogs
myofibrils
Dilated Cardiomyopathy
lysosomes
heart failure
myocardium
Lysosomes
fibrosis
Glycogen
glycogen
droplets

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Histological and ultrastructural evaluation of cardiac lesions in idiopathic cardiomyopathy in dogs. / Sandusky, George; Capen, C. C.; Kerr, K. M.

In: Canadian Journal of Comparative Medicine, Vol. 48, No. 1, 1984, p. 81-86.

Research output: Contribution to journalArticle

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