Histological evaluation of isolated rat heart preparations has shown that: Incubated isolated right ventricular strips and atria undergo observable degeneration after relatively short periods of time and at temperatures of 27° or higher. The degree of degeneration is a function of: (a) duration of incubation; (b) incubation temperature: and (c) thickness of the soaked preparation. Cardiac degeneration is not prevented by penicillin, streptomycin, polymyxin, chlorte-tracycline, 9-alpha-fluorohydrocortisone, or ouabain in the doses employed. The perfused whole heart is superior to the incubated isolated tissue preparation. The perfused heart shows few signs of degeneration at 37° for prolonged periods.
|Original language||English (US)|
|Number of pages||8|
|Journal||Proceedings of the Society for Experimental Biology and Medicine|
|State||Published - Nov 1968|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)