Histone mediated gene activation in Toxoplasma gondii

William J. Sullivan, Mohamed Ali Hakimi

Research output: Contribution to journalReview article

45 Scopus citations

Abstract

DNA processes, including transcriptional activation, are largely governed by histone modifications. For most eukaryotes, chromatin-remodeling machines have been identified that move, replace, or decorate histones. Recent studies have shed some important light on similar machinery operating in apicomplexan parasites, including the opportunistic pathogen Toxoplasma gondii. Here we present a synthesis of the current knowledge of histone mediated gene expression in Toxoplasma, particularly in the context of parasite differentiation.

Original languageEnglish (US)
Pages (from-to)109-116
Number of pages8
JournalMolecular and Biochemical Parasitology
Volume148
Issue number2
DOIs
StatePublished - Aug 1 2006

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Keywords

  • Apicomplexa
  • Chromatin
  • Differentiation
  • Parasite
  • Transcription

ASJC Scopus subject areas

  • Molecular Biology
  • Parasitology

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