Histone modifications: Implications in renal cell carcinoma

Swathi Ramakrishnan, Leigh Ellis, Roberto Pili

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

In 2012, an estimated 64,770 men and women were diagnosed with malignancy of the kidney and renal pelvis, of which 13,570 succumbed to their disease. Common genetic aberrations in renal cell carcinomas (RCCs) include loss of function of the VHL gene in clear-cell RCC, overexpression of the c-MET gene in papillary RCC type I, deficiency in the FH gene in papillary RCC type II and loss of heterozygozity of the BHD gene in chromophobe RCC. Recent studies illustrate epigenetic silencing of VHL, as well as alterations in histone modifications and their governing enzymes. The possibility of reversing these epigenetic marks has resulted in efforts to target these changes by utilizing inhibitors of HDACs, DNA methyltransferases and, recently, histone methyltransferases in preclinical and clinical studies. This article focuses on potential therapeutic interventions, and the implications of histone modifications and related enzyme alterations in RCC.

Original languageEnglish (US)
Pages (from-to)453-462
Number of pages10
JournalEpigenomics
Volume5
Issue number4
DOIs
StatePublished - Aug 2013

Keywords

  • DNA methyltransferase
  • HDAC
  • epigenetics
  • histone acetylation
  • histone methylation
  • renal cell carcinoma

ASJC Scopus subject areas

  • Genetics
  • Cancer Research

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