Histopathologic challenges: The second OPINION issue

Antonio Lopez-Beltran, Rita Canas-Marques, Liang Cheng, Rodolfo Montironi

Research output: Contribution to journalArticle

2 Scopus citations


Classification and definition criteria for rare cancer is still an open issue in clinical practice due to several factors, which include the limited available molecular data to better defining specific tumor groups or “families” of interest. An important issue related to the proper management of these entities is the correct diagnosis and subtyping of a given entity. The high complexity associated with the histopathologic diagnosis and eventual molecular analysis may suggest the use of a histopathologic second opinion from a specialized pathologist. Diagnostic inaccuracies and difference between primary diagnosis and second opinion are expected at the population level: however, the magnitude of this difference is remarkably high and calls for implementation of second opinion in routine practice outside reference centers.

Original languageEnglish (US)
JournalEuropean Journal of Surgical Oncology
StateAccepted/In press - Jan 1 2018


  • Diagnosis
  • Histopathology
  • Rare cancer
  • Second opinion

ASJC Scopus subject areas

  • Surgery
  • Oncology

Fingerprint Dive into the research topics of 'Histopathologic challenges: The second OPINION issue'. Together they form a unique fingerprint.

  • Cite this