Histopathological characterization of cholecystectomy specimens in patients with inflammatory bowel disease

Jingmei Lin, Bo Shen, Hwa Jeong Lee, John R. Goldblum

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background and aims: Inflammatory bowel disease is associated with increased risk of cholelithiasis. However, the histologic patterns in gallbladders have not been extensively studied. This study is designed to characterize the histopathologic features of cholecystectomy specimens in inflammatory bowel disease patients, compared to a control group. Methods: Cholecystectomy specimens in 78 Crohn's disease patients and 50 ulcerative colitis patients were reviewed. These were compared with 93 cholecystomies from noninflammatory bowel disease patients of approximate age and sex. The pattern and extent of inflammation was noted. Results: Marked chronic cholecystitis was present in 12% of ulcerative colitis patients (. P<. 0.05) and 10.3% of Crohn's disease patients (. P>. 0.05), compared to 4.3% of the noninflammatory bowel disease control group. Eight percent of ulcerative colitis patients (. P<. 0.05) and 2.6% of Crohn's disease patients (. P>. 0.05) had acute serositis, compared to 0% of the noninflammatory bowel disease control. The third inflammatory pattern, nodular lymphoid aggregates, was significantly increased in Crohn's disease patients after adjusting for the effect of cholelithiasis. Nodular lymphoid aggregates were found in 21.2% of Crohn's disease patients and 9.7% of ulcerative colitis patients without cholelithiasis, compared to 5% of noninflammatory bowel disease controls without cholelithiasis, a statistically significant difference between the Crohn's disease and control groups (. P<. 0.05). Conclusions: Inflammatory bowel disease patients show similar inflammatory patterns in cholecystectomy specimens compared to the general population. However, two inflammatory patterns that occur more often in ulcerative colitis patients are marked chronic cholecystitis and acute serositis, while nodular lymphoid aggregates are more common in Crohn's disease patients.

Original languageEnglish
Pages (from-to)895-899
Number of pages5
JournalJournal of Crohn's and Colitis
Volume6
Issue number9
DOIs
StatePublished - Oct 2012

Fingerprint

Cholecystectomy
Inflammatory Bowel Diseases
Ulcerative Colitis
Crohn Disease
Cholelithiasis
Serositis
Control Groups
Acute Cholecystitis
Cholecystitis
Gallbladder
Inflammation

Keywords

  • Cholecystectomy
  • Crohn's disease
  • Inflammatory bowel disease
  • Ulcerative colitis

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Histopathological characterization of cholecystectomy specimens in patients with inflammatory bowel disease. / Lin, Jingmei; Shen, Bo; Lee, Hwa Jeong; Goldblum, John R.

In: Journal of Crohn's and Colitis, Vol. 6, No. 9, 10.2012, p. 895-899.

Research output: Contribution to journalArticle

@article{3beb337bf357464b9703123f5403479c,
title = "Histopathological characterization of cholecystectomy specimens in patients with inflammatory bowel disease",
abstract = "Background and aims: Inflammatory bowel disease is associated with increased risk of cholelithiasis. However, the histologic patterns in gallbladders have not been extensively studied. This study is designed to characterize the histopathologic features of cholecystectomy specimens in inflammatory bowel disease patients, compared to a control group. Methods: Cholecystectomy specimens in 78 Crohn's disease patients and 50 ulcerative colitis patients were reviewed. These were compared with 93 cholecystomies from noninflammatory bowel disease patients of approximate age and sex. The pattern and extent of inflammation was noted. Results: Marked chronic cholecystitis was present in 12{\%} of ulcerative colitis patients (. P<. 0.05) and 10.3{\%} of Crohn's disease patients (. P>. 0.05), compared to 4.3{\%} of the noninflammatory bowel disease control group. Eight percent of ulcerative colitis patients (. P<. 0.05) and 2.6{\%} of Crohn's disease patients (. P>. 0.05) had acute serositis, compared to 0{\%} of the noninflammatory bowel disease control. The third inflammatory pattern, nodular lymphoid aggregates, was significantly increased in Crohn's disease patients after adjusting for the effect of cholelithiasis. Nodular lymphoid aggregates were found in 21.2{\%} of Crohn's disease patients and 9.7{\%} of ulcerative colitis patients without cholelithiasis, compared to 5{\%} of noninflammatory bowel disease controls without cholelithiasis, a statistically significant difference between the Crohn's disease and control groups (. P<. 0.05). Conclusions: Inflammatory bowel disease patients show similar inflammatory patterns in cholecystectomy specimens compared to the general population. However, two inflammatory patterns that occur more often in ulcerative colitis patients are marked chronic cholecystitis and acute serositis, while nodular lymphoid aggregates are more common in Crohn's disease patients.",
keywords = "Cholecystectomy, Crohn's disease, Inflammatory bowel disease, Ulcerative colitis",
author = "Jingmei Lin and Bo Shen and Lee, {Hwa Jeong} and Goldblum, {John R.}",
year = "2012",
month = "10",
doi = "10.1016/j.crohns.2012.02.002",
language = "English",
volume = "6",
pages = "895--899",
journal = "Journal of Crohn's and Colitis",
issn = "1873-9946",
publisher = "Elsevier",
number = "9",

}

TY - JOUR

T1 - Histopathological characterization of cholecystectomy specimens in patients with inflammatory bowel disease

AU - Lin, Jingmei

AU - Shen, Bo

AU - Lee, Hwa Jeong

AU - Goldblum, John R.

PY - 2012/10

Y1 - 2012/10

N2 - Background and aims: Inflammatory bowel disease is associated with increased risk of cholelithiasis. However, the histologic patterns in gallbladders have not been extensively studied. This study is designed to characterize the histopathologic features of cholecystectomy specimens in inflammatory bowel disease patients, compared to a control group. Methods: Cholecystectomy specimens in 78 Crohn's disease patients and 50 ulcerative colitis patients were reviewed. These were compared with 93 cholecystomies from noninflammatory bowel disease patients of approximate age and sex. The pattern and extent of inflammation was noted. Results: Marked chronic cholecystitis was present in 12% of ulcerative colitis patients (. P<. 0.05) and 10.3% of Crohn's disease patients (. P>. 0.05), compared to 4.3% of the noninflammatory bowel disease control group. Eight percent of ulcerative colitis patients (. P<. 0.05) and 2.6% of Crohn's disease patients (. P>. 0.05) had acute serositis, compared to 0% of the noninflammatory bowel disease control. The third inflammatory pattern, nodular lymphoid aggregates, was significantly increased in Crohn's disease patients after adjusting for the effect of cholelithiasis. Nodular lymphoid aggregates were found in 21.2% of Crohn's disease patients and 9.7% of ulcerative colitis patients without cholelithiasis, compared to 5% of noninflammatory bowel disease controls without cholelithiasis, a statistically significant difference between the Crohn's disease and control groups (. P<. 0.05). Conclusions: Inflammatory bowel disease patients show similar inflammatory patterns in cholecystectomy specimens compared to the general population. However, two inflammatory patterns that occur more often in ulcerative colitis patients are marked chronic cholecystitis and acute serositis, while nodular lymphoid aggregates are more common in Crohn's disease patients.

AB - Background and aims: Inflammatory bowel disease is associated with increased risk of cholelithiasis. However, the histologic patterns in gallbladders have not been extensively studied. This study is designed to characterize the histopathologic features of cholecystectomy specimens in inflammatory bowel disease patients, compared to a control group. Methods: Cholecystectomy specimens in 78 Crohn's disease patients and 50 ulcerative colitis patients were reviewed. These were compared with 93 cholecystomies from noninflammatory bowel disease patients of approximate age and sex. The pattern and extent of inflammation was noted. Results: Marked chronic cholecystitis was present in 12% of ulcerative colitis patients (. P<. 0.05) and 10.3% of Crohn's disease patients (. P>. 0.05), compared to 4.3% of the noninflammatory bowel disease control group. Eight percent of ulcerative colitis patients (. P<. 0.05) and 2.6% of Crohn's disease patients (. P>. 0.05) had acute serositis, compared to 0% of the noninflammatory bowel disease control. The third inflammatory pattern, nodular lymphoid aggregates, was significantly increased in Crohn's disease patients after adjusting for the effect of cholelithiasis. Nodular lymphoid aggregates were found in 21.2% of Crohn's disease patients and 9.7% of ulcerative colitis patients without cholelithiasis, compared to 5% of noninflammatory bowel disease controls without cholelithiasis, a statistically significant difference between the Crohn's disease and control groups (. P<. 0.05). Conclusions: Inflammatory bowel disease patients show similar inflammatory patterns in cholecystectomy specimens compared to the general population. However, two inflammatory patterns that occur more often in ulcerative colitis patients are marked chronic cholecystitis and acute serositis, while nodular lymphoid aggregates are more common in Crohn's disease patients.

KW - Cholecystectomy

KW - Crohn's disease

KW - Inflammatory bowel disease

KW - Ulcerative colitis

UR - http://www.scopus.com/inward/record.url?scp=84865782369&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84865782369&partnerID=8YFLogxK

U2 - 10.1016/j.crohns.2012.02.002

DO - 10.1016/j.crohns.2012.02.002

M3 - Article

C2 - 22397872

AN - SCOPUS:84865782369

VL - 6

SP - 895

EP - 899

JO - Journal of Crohn's and Colitis

JF - Journal of Crohn's and Colitis

SN - 1873-9946

IS - 9

ER -